Follow us, bookmark us, and meet us every day at 7:30 for daily Java content sharing. Technical Analysis HTTP messages are divided into request messages (client -> server) and response messages (server -> client). 1. Structure of HTTP Request Message The request message is used to tell the server “what I want to do.” # … Read more
ADC is known as precision therapy, which delivers drugs precisely to tumor cells through targeted antibodies, maximizing the destruction of tumors while minimizing damage to normal tissues. In the design of ADC, antibodies are responsible for “navigation,” while the payload (toxin) is the true “terminator.” This article will discuss the classification of mainstream ADC payloads, … Read more
ADC is known as precision therapy, which delivers drugs precisely to tumor cells through targeted antibodies, maximizing tumor destruction while minimizing damage to normal tissues. In the design of ADC, antibodies are responsible for “navigation,” while the payload (toxin) is the true “terminator.” This article will delve into the classification of mainstream ADC payloads, why … Read more
On November 12, Sutro held its R&D Day event. With the complete termination of the original pillar product FRα, Sutro’s situation is not optimistic. The focus of this R&D Day event remains on ADCs.Related Reading: Sutro 25H1: ROR1 is returned, continuing to push the dual payload platformSutro pointed out that its platform expands the therapeutic … Read more
The emergence of T-DXd represents a significant breakthrough in the treatment of HER2-positive and HER2-low expressing breast cancer. However, like any effective anti-cancer therapy, acquired resistance remains a major challenge affecting the long-term benefits for patients. Since the launch of Trastuzumab emtansine in 2013, five HER2 ADCs have been approved:Table 1: Approved HER ADCsAs clinical … Read more
The ADC Field Is Flourishing, with new technologies evolving like a raging torrent, propelling biomedicine into a sprint mode, this is the best of times. As early as the beginning of the 20th century, Paul Ehrlich first proposed the concept of the “magic bullet”, but the first ADC drug Mylotarg® (gemtuzumab ozogamicin) was not approved … Read more
Payload The early developed ADCs used FDA-approved anticancer agent small molecule payloads, such as DM1 and vincristine, but these drugs have poor toxicity. Due to the large size of ADCs, it is estimated that only about 2% of ADCs are effectively internalized, thus more toxic payloads have been developed as ADC payloads, most of which … Read more
The tumor distribution of ADCs depends on many factors, includingthe dose itself, systemic clearance rate, antigen expression level, endocytosis rate, and the tumor’s surface area to volume ratio (S/V). Poor tissue permeability remains a major challenge for antibody treatments of solid tumors, and appropriately increasing the dosage can improve the drug’s tissue distribution and enhance … Read more
1 Introduction Antibody-drug conjugates (ADC) are an emerging technology that selectively targets cancer cells to overcome the limitations of chemotherapy.ADC binds to antigens, especially those overexpressed on the surface of cancer cells, reducing side effects caused by nonspecific targeting and improving the therapeutic index. The idealADC efficacy relies entirely on several physicochemical factors, such as … Read more
Author｜Wenxin As of now, regarding thetoxicity of ADCs in solid tumors and preventive measures, the following is known: ① The indications for ADCs are rapidly expanding, gradually shifting from late-stage to early-stage, and from single therapy to combination strategies. ② The toxicity characteristics of most ADCs are similar to the cytotoxicity of their payloads. ③ … Read more