As of now, the toxicity and prevention measures of ADC in solid tumors are known as follows: ① The indications for ADCs are rapidly expanding, gradually shifting from late-stage to early-stage, and from single therapy to combination strategies. ② The toxicity characteristics of most ADCs are similar to the cytotoxicity of their payloads. ③ Certain … Read more
Key Content Preview:In recent years, antibody-drug conjugates (ADCs) have developed rapidly. As of August 2023, there are a total of 15 ADCs on the market globally, with over 1200 drugs under research. In June this year, Nature Biotechnology published a brief report titled “ADCs’ Revival”, highlighting the “breakthrough momentum” of ADCs in new drug development. … Read more
1 Introduction Antibody-drug conjugates (ADCs) are a new type of highly effective biopharmaceuticals that link antibodies with biologically active small molecule cytotoxic payloads through linkers. ADCs are designed to improve the therapeutic index (TI) of chemotherapeutic agents by selectively delivering cytotoxic drugs to tumor cells while reducing exposure in normal cells. Despite using a large … Read more
National Certification Remote Forensic Base With You . . Learning and Practicing AbstractWith the rapid development of artificial intelligence (AI), the intersection of forensic toxicology and AI has increasingly become a research hotspot in forensic science, providing new ideas and methods to solve traditional forensic toxicology issues. This article reviews recent domestic and international research, … Read more