Recent Advances in Antibody-Drug Conjugates (ADCs) Development and Considerations for Non-Clinical Review

Recent Advances in Antibody-Drug Conjugates (ADCs) Development and Considerations for Non-Clinical Review

Introduction As one of the most active innovative drug development areas at present, Antibody-Drug Conjugates (ADCs) are rising at an astonishing pace. The global industry interest continues to heat up, with ADC innovative drugs being approved one after another. As of March 2025, a total of 17 ADC products have been approved for market release … Read more

Can Vitamin C Prevent and Treat COVID-19? Insights from Pharmacists

Can Vitamin C Prevent and Treat COVID-19? Insights from Pharmacists

According to a report from Health Times on February 14, the team led by Professor Peng Zhiyong at Zhongnan Hospital of Wuhan University is conducting clinical trials on high-dose Vitamin C treatment for COVID-19, suggesting that Vitamin C may be used for treating COVID-19. Professor Peng Zhiyong explained that the dosage of Vitamin C used … Read more

A Comprehensive Guide to Non-Clinical Pharmacology and Toxicology Assessment of ADCs

A Comprehensive Guide to Non-Clinical Pharmacology and Toxicology Assessment of ADCs

Recently, ADC (Antibody-Drug Conjugate) conferences have been held one after another, with major biotech companies competing to report their ADC pipelines. It is expected that 2024 will still be the main venue for ADCs. Developing an entry-level ADC seems not difficult, but evaluating the pharmacology and toxicology in the preclinical stage has become a top … Read more

Introduction to ADC: A Brief Overview of Clinical Pharmacology

Introduction to ADC: A Brief Overview of Clinical Pharmacology

Introduction Antibody-drug conjugates (ADC) are comprised of monoclonal antibodies that target specific antigens linked to small molecule cytotoxic drugs via a linker, combining the powerful killing effects of traditional small molecule chemotherapy with the tumor-targeting properties of antibody drugs. Since the first ADC (Gemtuzumab-ozogamicin (trade name: Mylotarg)) was approved for the treatment of CD33-positive acute … Read more

Fundamentals of Clinical Pharmacology of ADCs

Antibody-drug conjugates (ADC) are formed by linking monoclonal antibodies that target specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs. Since the first ADC (Gemtuzumab-ozogamicin, trade name: Mylotarg) was approved for the treatment of CD33-positive acute myeloid … Read more