Recently, the WeChat update has disrupted the release schedule, causing many readers to miss article updates. Please set “Fengkou Research” as a star ⭐ so we can move forward together and see each other every day! ADC, a potential new star in the field of innovative drugs In the vast starry sky of innovative drugs, … Read more
Cuproptosis is a novel copper-dependent programmed cell death mechanism, which centers on the interaction between copper ions and acylated proteins in the tricarboxylic acid (TCA) cycle, leading to protein aggregation and mitochondrial dysfunction, ultimately resulting in cell death. This mechanism provides new insights for cancer treatment, as the accumulation of copper ions in tumor cells … Read more
This article has a total of2229words, reading time:3-4 minutes ｜Author: MaxTom On May 29, 2025, Merck and Daiichi Sankyo jointly announced thevoluntary withdrawal of the market application for the HER3-targeted antibody-drug conjugate (ADC), Patritumab deruxtecan (HER3-DXd), which was originally seeking accelerated approval for the treatment of patients with advanced non-small cell lung cancer (NSCLC) who … Read more
1. Overview of ADC Drugs Antibody-drug conjugates (ADCs) are referred to as the ‘magic bullets’ for cancer treatment. They are a new type of biotherapeutic drug that combines monoclonal antibodies with cytotoxic drugs through a chemical linker. The core concept is to combine the specific targeting ability of antibodies with the powerful killing effect of … Read more
–01– Introduction The announcement of the 2022 Nobel Prize in Chemistry brought the cutting-edge technology of “Click Chemistry” into the public eye. The groundbreaking work of three scientists has not only revolutionized the field of organic synthesis but also opened new pathways for cancer treatment—specifically, the development of Antibody-Drug Conjugates (ADC) is advancing towards a … Read more
The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting grandly opened in Chicago on May 31, lasting for 4 days, with the theme “Driving Knowledge to Action: Building a Better Future,” focusing on the latest research progress and innovative translational achievements in the global cancer treatment field. ADC drugs remain a hot area of … Read more
We previously mentioned that the current standard treatment for cancer is gradually shifting from PD-1 + chemotherapy to PD-1 + ADC drugs. According to relevant data, the global ADC drug market size has grown from $7.9 billion in 2022 to approximately $20 billion in 2024, showing strong growth momentum. Among them, DS8201 (HER2 ADC), jointly … Read more
In cancer treatment, there are three targeted approaches to enhance the specificity and anti-tumor activity of therapies. Targeted formulations can be designed to inhibit proteins expressed by tumor cells, such as receptors or enzymes; another approach involves binding effector molecules (e.g., ADCs, bispecific antibodies, or CAR-T) to molecules overexpressed on the surface of tumor cells, … Read more
In the field of cancer immunotherapy, activating STING (Stimulator of Interferon Genes) is a key strategy to stimulate anti-cancer immune responses. STING, as an important innate immune protein, enhances anti-cancer immunity through type I interferon signaling. However, traditional STING agonists face numerous challenges during intravenous administration, such as short blood circulation half-life and insufficient tumor … Read more
The limbs of the LEGO figure in the image can move independently because the magnetic screws connecting its limbs are in a specially designed layered magnetic field. On February 23, Beijing time, foreign media reported that a recent study suggests that magnetically controlled microrobots may one day help us combat cancer. Over the past decade, … Read more