01 Domestic B7H3 ADC: From Clinical Data to Market Ambitions In 2024, the global ADC landscape is set to reach a turning point amidst the celebration of DS-8201 breaking the $10 billion expectation, with the B7H3 target emerging as a dark horse and becoming the next storm center. Taking domestic products as an example, although … Read more
Xinge Corporation (headquartered in Nagoya, Aichi Prefecture, Japan) recently announced that non-clinical data for its novel antibody-drug conjugate (ADUC) K-679 will be officially presented at the American Association for Cancer Research (AACR) Annual Meeting 2025, scheduled to take place from April 25 to 30, 2025, in Chicago, Illinois, USA. K-679 K-679 is an antibody-drug conjugate … Read more
Bay Area Medical Breakthroughs 3D-Printed Hearts, Electronic Skin, Brain “Microscopes” 3D-Printed Hearts have emerged, Are they usable? Are they reliable? Is the electronic skin for human-machine symbiosis here? Will prosthetic patients regain their sense of touch? How can a 1.7-gram “Brain Observer” assist breakthroughs in Alzheimer’s treatment? These scenarios, which sound like science fiction, are … Read more
Background Introduction UV-emitting materials in the ultraviolet spectrum play an irreplaceable role in various fields such as photocatalytic degradation of pollutants, information anti-counterfeiting, medicine, phototherapy, environmental disinfection (water/air purification), and spectral analysis due to their high-energy photon characteristics. To meet the demands of these applications, scientists have developed various types of UV-emitting materials, including colloidal … Read more
Click the blue text Follow us Background Introduction Hypoxia has been identified as a prominent feature within tumors, resulting from the rapid and aggressive growth of tumor cells and abnormal vascularization. Consequently, the low concentration of oxygen (O2) in the hypoxic tumor microenvironment significantly weakens O2-dependent physiological mechanisms and further reduces therapeutic efficacy, such as … Read more
Written by丨Wang CongEdited by丨Wang DuoyuTypeset by丨Shui ChengwenBacteria are attracted to chemical gradients, such as low oxygen levels or high acidity, which are commonly found near tumor tissues. Injecting bacteria near tumor tissues for cancer treatment is known as bacterial-mediated tumor therapy.Bacteria accumulate in tumor tissues and grow within them, activating the patient’s immune system to … Read more
Follow Xiaobai Learning Medicine As of now, 17 ADC drugs have been approved worldwide, of which 5 ADCs are coupled with lysine. Table 1 Summary of ADC Drugs Coupled with Lysine Approved Product Name Company Target DAR Toxin Linker Antibody Type Payload Type Mylotarg Pfizer CD33 2~3 Calicheamicin Hydrazone Link (Acid-labile) IG4 DNA Damaging Agent … Read more
Follow us to receive such great articles every day! WeChat ID:kqjy360 Authors: Tang Xiaoyu, Gu Dongkun, Li Dong, Niu Qianyun, Nanyang Dental Hospital; Wu Dandan, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Dental School Oral-Facial-Digital Syndrome (OFDS) is a unique developmental genetic disorder characterized by malformations of the mouth, face, … Read more
The AACR is always bustling every year, and this year I am particularly focused on the progress of dual payload ADCs. I have written several articles on this topic before, and just a few days ago, I was discussing with my supervisor that “I haven’t seen any dual payload ADCs advancing to clinical trials yet,” … Read more
If a few years ago, presenting a simple PowerPoint on the ADC field could impress without the need for future visions, cutting-edge technologies, or a vibrant pipeline forest, today, the ADC field requires substantial content to make an impact. This shift is attributed to advancements in industry technology and rising awareness. Data shows that from … Read more