Follow Xiaobai Learning Medicine As of now, 17 ADC drugs have been approved worldwide, of which 5 ADCs are coupled with lysine. Table 1 Summary of ADC Drugs Coupled with Lysine Approved Product Name Company Target DAR Toxin Linker Antibody Type Payload Type Mylotarg Pfizer CD33 2~3 Calicheamicin Hydrazone Link (Acid-labile) IG4 DNA Damaging Agent … Read more
Follow us to receive such great articles every day! WeChat ID:kqjy360 Authors: Tang Xiaoyu, Gu Dongkun, Li Dong, Niu Qianyun, Nanyang Dental Hospital; Wu Dandan, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Dental School Oral-Facial-Digital Syndrome (OFDS) is a unique developmental genetic disorder characterized by malformations of the mouth, face, … Read more
The AACR is always bustling every year, and this year I am particularly focused on the progress of dual payload ADCs. I have written several articles on this topic before, and just a few days ago, I was discussing with my supervisor that “I haven’t seen any dual payload ADCs advancing to clinical trials yet,” … Read more
If a few years ago, presenting a simple PowerPoint on the ADC field could impress without the need for future visions, cutting-edge technologies, or a vibrant pipeline forest, today, the ADC field requires substantial content to make an impact. This shift is attributed to advancements in industry technology and rising awareness. Data shows that from … Read more
【Citation Format】Li Mian, Tan Zhonglin, Wu Yue, et al. Research advances in glutamate and γ-aminobutyric acid homeostasis imbalance in major depressive disorder[J]. Chinese Journal of Nervous and Mental Diseases, 2023, 49(12): 758-764. 【Cite this article】LI Mian, TAN Zhonglin, WU Yue, et al. Research advances in glutamate and γ-aminobutyric acid homeostasis imbalance in major depressive disorder[J]. … Read more
The Concept and Development History of ADC The treatment of tumors has always undergone a continuous transformation from theory to application, breaking and transforming again. As early as a century ago, scholars proposed the concept of antibody-drug conjugates (ADCs), vividly calling them “magic bullets,” aimed at targeting specific antigens that may exist on the surface … Read more
Since the first use of cytotoxic chemicals to treat cancer, oncologists have been searching for ways to enhance efficacy without significantly increasing overall toxicity to patients. One of the methods attempted to improve the killing effect on tumor cells is the use of cytotoxic agents with potency at picomolar or lower levels (such as microtubule … Read more
Medical researchers are not only continuously developing new anti-tumor drugs but are also trying to find new uses for old drugs, hoping to alleviate the suffering caused by cancer and extend survival. High-dose vitamin C treatment for cancer is one of these methods, which is still under research. Many people may wonder how vitamin C, … Read more
To deliver chemotherapy drugs more effectively, small molecule drug conjugates (SMDC), antibody-drug conjugates (ADC), and degrader-antibody conjugates (DAC) have been explored and developed, providing selective delivery while improving the therapeutic index. What are their similarities and differences? What are their respective advantages? What is the current state of research? What does the future hold? This … Read more
Welcome to reprint, please note the source “Jiangcheng ITP Home”🎉🎉🎉 Decitabine (DAC) is commonly known as an anticancer drug, clinically used for the treatment of myelodysplastic syndromes (MDS), acute myeloid leukemia, chronic myelomonocytic leukemia, and other malignant hematological diseases,because it has demethylation and cytotoxic effects, which can induce cell death. However, its “magical” efficacy in … Read more