Cytotoxic Agent

Key Factors Affecting ADC Efficacy

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Key Factors Affecting ADC Efficacy

1 Introduction Antibody-drug conjugates (ADC) are an emerging technology that selectively targets cancer cells to overcome the limitations of chemotherapy.ADC binds to antigens, especially those overexpressed on the surface of cancer cells, reducing side effects caused by nonspecific targeting and improving the therapeutic index. The idealADC efficacy relies entirely on several physicochemical factors, such as … Read more

In-Depth Analysis of Antibody-Drug Conjugates (ADC) – Part 3

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In-Depth Analysis of Antibody-Drug Conjugates (ADC) - Part 3

Introduction Antibody-drug conjugates (ADCs) are “biological bullets” formed by conjugating cytotoxic drugs (payloads) to antibodies via a “linker.” They consist of five components: target, antibody, linker, payload, and conjugation method. Each part is crucial to the function of ADCs, but today we will focus on the linker that connects the antibody and payload, examining the … Read more