Bottlenecks in ADC Drug Efficacy
The tumor distribution of ADCs depends on many factors, includingthe dose itself, systemic clearance rate, antigen expression level, endocytosis rate, and the tumor’s surface area to volume ratio (S/V). Poor tissue permeability remains a major challenge for antibody treatments of solid tumors, and appropriately increasing the dosage can improve the drug’s tissue distribution and enhance … Read more
