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Clinical Development Strategies for Antibody-Drug Conjugates (ADCs)

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Clinical Development Strategies for Antibody-Drug Conjugates (ADCs)

Due to the differences in selecting target antigens, effective payloads, linkers, and conjugation methods for antibody-drug conjugates (ADCs), there is structural diversity and complexity. Moreover, ADCs cannot simply be equated to a combination of antibodies and effective payloads, as there are numerous challenges in clinical development, including the complexity of pharmacokinetics, insufficient tumor targeting, payload … Read more

World’s First Dual Payload ADC Clinical Data Released

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World's First Dual Payload ADC Clinical Data Released

Author:Bio-four Introduction On March 26, 2025, the TROP2 dual payload ADC drug KH815 developed by Kanghong Biotech received clinical trial approval from the Australian HREC and obtained clinical approval in China on April 16, 2025, making it the world’s first dual payload ADC approved for clinical use.During this year’s AACR conference and related patents made … Read more

Nikon’s New Patent Enhances Sensor Dynamic Range and Read Speed

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Nikon's New Patent Enhances Sensor Dynamic Range and Read Speed

Nikon’s new sensor design patent technology Aiming at dynamic range and read speed In a recent patent application submitted by Nikon, an image sensor with a larger dynamic range and higher read speed is described. This patent indicates that camera sensor technology is about to enter a new stage. It is a multi-layer stacked image … Read more

Successful Casting of the First Single Blade Product by the New Sand Molding Milling Robot – A New Milestone in the Intelligent Transformation of the Foundry Industry

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Successful Casting of the First Single Blade Product by the New Sand Molding Milling Robot - A New Milestone in the Intelligent Transformation of the Foundry Industry

Recently, the Dalian Marine Propulsion Company, a subsidiary of China Shipbuilding Industry Corporation, successfully completed the casting process of the first single blade product 115K developed in collaboration with the Wuxi Research Institute of Huazhong University of Science and Technology. Testing showed that the dimensional accuracy and surface finish of the casting met the preset … Read more

New Clinical Application of Henlius PD-L1 ADC-HLX43 in China Amidst Data Overload

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New Clinical Application of Henlius PD-L1 ADC-HLX43 in China Amidst Data Overload

HLX43 for injection is an innovative targeted PD-L1 antibody-drug conjugate (ADC) developed in collaboration between Henlius Biotech Co., Ltd. and Suzhou Yilian Biotechnology Co., Ltd. This drug is based on a fully humanized IgG1 anti-PD-L1 monoclonal antibody, conjugated with a novel tripeptide linker and a topoisomerase I inhibitor (derived from camptothecin compounds), forming a stable … Read more

Lukangsatuzumab: A Domestic TROP2 ADC Cancer Treatment Star, Multiple Phase III Studies Top International Journals

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Lukangsatuzumab: A Domestic TROP2 ADC Cancer Treatment Star, Multiple Phase III Studies Top International Journals

The medical community welcomes a new “weapon” against cancer, as a domestic innovative drug demonstrates outstanding performance in the treatment of lung cancer and breast cancer, bringing new hope to advanced patients.At the 2025 European Society for Medical Oncology (ESMO) annual meeting, a domestically developed innovative antibody-drug conjugate—Lukangsatuzumab (Sac-TMT, Jiatai Lai®)—announced multiple Phase III clinical … Read more

PCB Design Specifications: ADC/DAC Design Guidelines

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PCB Design Specifications: ADC/DAC Design Guidelines

Documenting work, sharing experiences, and open-sourcing! Speed up! Committed to ensuring that every step of our design is theoretically supported! Star and follow = progress together. Be sure to check the comments section, as some colleagues will discuss and supplement there, enriching this theoretical library together! Documentation is getting more concise! CPU is burning up … Read more

The Future of Self-Immunization ADCs

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The Future of Self-Immunization ADCs

Recently, there has been a piece of news that is quite eye-catching.On November 19, 2025, the ADC biotechnology company Lifordi Immunotherapeutics announced the completion of a new round of strategic financing amounting to $42 million. The funds will primarily be used for ADCs beyond oncology—specifically, LFD-200, which targets VISTA, one of the most competitive emerging … Read more

ADC Overview: The Technical Landscape of ‘Biological Missiles’

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ADC Overview: The Technical Landscape of 'Biological Missiles'

🔬 Introduction From Paul Ehrlich’s concept of the “magic bullet” in the early 20th century to the approval of the first ADC drug Mylotarg in 2000, antibody-drug conjugates (ADCs) have undergone a century of evolution and have become a “star therapy” in the field of precision oncology. This “biological missile,” which combines the targeting ability … Read more