T-DM1

Understanding ADC Drug Resistance Mechanisms

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Understanding ADC Drug Resistance Mechanisms

1. Mechanism of ADC Action Antibody-drug conjugates (ADC) (Click to enter the database to search for global ADC drug information) enter the body, the antibody part binds to the targeted antigen on the surface of tumor cells, tumor cells will endocytose the ADC molecule. Among them, some can bind to Fc receptors in the endosome, … Read more

Overview of ADC Drugs for Breast Cancer

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Overview of ADC Drugs for Breast Cancer

As early as 1913, during the 17th International Medical Congress, Professor Paul Ehrlich proposed the concept of the “magic bullet”, using monoclonal antibodies to specifically deliver cytotoxic drugs to tumor cells, thereby achieving the goal of killing tumor cells. With the development of monoclonal antibody production technology and the exploration of antibody conjugates, antibody-drug conjugates … Read more