Understanding TCP Through a Historical Analogy

Understanding TCP Through a Historical Analogy

Introduction: This article aims to discuss knowledge about TCP. Please forgive any inappropriate metaphors. In the fourth year of the Tianqi era of the Ming Dynasty, early morning. As dawn broke, I drove a horse-drawn cart full of goods to the South City Gate, which was the central location for handling goods. A line of … Read more

Degrader-Antibody Conjugates: Risks on the Path from Concept to Reality

Degrader-Antibody Conjugates: Risks on the Path from Concept to Reality

01 DAC‘s Emergence and Advantages Cancer therapeutics need to balance efficacy and safety, even targeted chemotherapy does not always only kill abnormal cancer cells, and non-specific toxicity can lead to a low therapeutic index and side effects. The technology of Proteolysis-targeting chimeras (PROTACs), which achieve therapeutic effects by promoting the degradation of target proteins, is … Read more

One-Step Formation Method of Sperm-Like Structure Microrobots for Drug Delivery

One-Step Formation Method of Sperm-Like Structure Microrobots for Drug Delivery

Sperm-Like Microrobots have broad application prospects in biomedicine, especially in precise drug delivery and minimally invasive surgery. However, traditional microrobots face challenges such as complex manufacturing processes, high material requirements, and poor environmental adaptability. Professor Shen Yajing’s research team at the Hong Kong University of Science and Technology proposed a vortex turbulence-assisted microfluidic platform (VTAM) … Read more

Preparation and Characterization of ROS-Responsive Bletilla Striata Polysaccharide Drug-Loaded Micelles

Preparation and Characterization of ROS-Responsive Bletilla Striata Polysaccharide Drug-Loaded Micelles

Bletilla striata polysaccharide (BSP) is a polysaccharide extracted from the medicinal material Bletilla striata, composed of mannose and glucose (2.4:1) linked by β-glycosidic bonds. It exhibits biological activities such as anti-inflammation, antioxidant, and anti-fibrosis [1], and is non-toxic, biodegradable, and highly compatible, making it widely used in drug formulation [2-6]. Additionally, literature reports that BSP … Read more

Degrader-Antibody Conjugates: The Risky Path from Concept to Reality

Degrader-Antibody Conjugates: The Risky Path from Concept to Reality

The Emergence and Advantages of DAC Cancer therapeutics need to achieve a balance between efficacy and safety, even targeted chemotherapy does not always only kill abnormal cancer cells, non-specific toxicity can lead to a low therapeutic index and side effects. The technology of proteolysis-targeting chimeras (PROTACs), which achieves therapeutic effects by promoting the degradation of … Read more

Acoustic Actuators for Micro/Nanorobot Manipulation: Current and Future Perspectives

Acoustic Actuators for Micro/Nanorobot Manipulation: Current and Future Perspectives

Cao HX, Nguyen VD, Park JO, Choi E, Kang B. Acoustic Actuators for the Manipulation of Micro/Nanorobots: State-of-the-Art and Future Outlooks. Micromachines (Basel). 2024 Jan 26;15(2):186. doi: 10.3390/mi15020186. PMID: 38398914; PMCID: PMC10890471. Compared to other actuation methods, acoustic actuators have the unique capability of non-contact operation of small objects (such as micro and nanoscale robots). … Read more

Stanford Team Develops Millirobot for Precision Drug Delivery

Stanford Team Develops Millirobot for Precision Drug Delivery

When we are sick, what we hope for most is a miraculous medicine that can cure us instantly after swallowing. However, the pain still lingers, and you are left waiting for it to subside. In reality, drugs do not always target the pain point as precisely as you wish. Therefore, their efficacy becomes like Schrödinger’s … Read more

Transforming Bacteria into Microrobots for Targeted Drug Delivery in Cancer Treatment

Transforming Bacteria into Microrobots for Targeted Drug Delivery in Cancer Treatment

Written by丨Wang Cong Edited by丨Wang Duoyu Typeset by丨Shui Chengwen Bacteria are attracted to chemical gradients, such as low oxygen levels or high acidity, both of which are commonly found near tumor tissues. Injecting bacteria near tumor tissues for cancer treatment is known as bacteria-mediated tumor therapy. The bacteria accumulate in the tumor tissue and grow, … Read more

Microrobots for Drug Delivery: Rolling and Swimming Capabilities

Microrobots for Drug Delivery: Rolling and Swimming Capabilities

Click Jiangsu Laser Industry Technology Innovation Strategic Alliance Follow/ Pin Public Account News | Technical Article | Conference Forum | Processing Services Jiangsu Laser Alliance Introduction: The microrobotic system includes unconfined rolling magnetic microrobots, two-degree-of-freedom rotating permanent magnets, and ultrasound imaging systems, which have been developed for both in vitro and in vivo biomedical applications. … Read more

Sperm, Bacteria, Bubbles, and Bioastronauts: Microbots to Combat Cancer

Sperm, Bacteria, Bubbles, and Bioastronauts: Microbots to Combat Cancer

Sperm, bacteria, bubbles, and bioastronauts are set to become the latest microbots developed for human use in cancer treatment over the coming years. Microscopic robots rolling through blood vessels, drilling into the brain, and swimming in the intestines are no longer scenes from science fiction movies. Scientists and engineers are developing microbots, ranging from the … Read more