Key Components and Mechanisms of ADC Stability The instability of linkers in the bloodstream (also known as premature payload release) is a major factor limiting the therapeutic index of ADCs. Stabilization technologies are strategies to improve the therapeutic window. If the drug cannot be linked to the ADC, it cannot be delivered directly to tumor … Read more
In the field of cancer immunotherapy, activating STING (Stimulator of Interferon Genes) is a key strategy to stimulate anti-cancer immune responses. STING, as an important innate immune protein, enhances anti-cancer immunity through type I interferon signaling. However, traditional STING agonists face numerous challenges during intravenous administration, such as short blood circulation half-life and insufficient tumor … Read more
Ophthalmology Innovative Approach New Antibiotic-Loaded Intraocular Lens Effectively Prevents and Treats Post-Cataract Endophthalmitis Postoperative endophthalmitis is a serious complication of ocular surgery that can lead to vision loss and globe atrophy, commonly occurring after cataract surgery, with an incidence rate of 0.012% to 1.3% globally over the past 20 years. Current preventive methods for endophthalmitis … Read more
Author | Yufei Men Editor | New Story First Published | Global Intelligent Business ▍Image Source: Internet In the internet era, people often use the term “brain hole” to describe some of the strange ideas from netizens. In fact, even before the internet appeared, there were plenty of “brain holes”. For example, the Hollywood movie … Read more
Introduction Microrobots can deliver drugs inside the human body On May 31, reported by Wang Ziyu, taking medicine is one of the necessary experiences in life, but for many children and even some adults, taking medicine can be a very difficult task. Additionally, some individuals cannot effectively absorb the medication due to physical reasons. To … Read more
In this issue, the author introduces the entire process of design to application of microrobots in medical systems, discussing the current technological level and the challenges faced. Microrobots, ranging in size from a few micrometers to several millimeters, can access complex anatomical areas within the human body that are difficult to reach, enabling targeted drug … Read more
Excessive reactive oxygen species, damage to the epithelial barrier, immune dysregulation, and imbalance of the gut microbiota are key factors leading to the onset of inflammatory bowel disease (IBD) and complicating its treatment. Timely diagnosis of the disease and precise delivery of therapeutic drugs to the inflamed intestinal sites is a targeted strategy that can … Read more
Written by丨Wang CongEdited by丨Wang DuoyuTypeset by丨Shui ChengwenBacteria are attracted to chemical gradients, such as low oxygen levels or high acidity, which are commonly found near tumor tissues. Injecting bacteria near tumor tissues for cancer treatment is known as bacterial-mediated tumor therapy.Bacteria accumulate in tumor tissues and grow within them, activating the patient’s immune system to … Read more
The abstract from AACR hides a new modality. Following yesterday’s TCE conjugated ADC, there is also the Triple-payload ADC project submitted by Araris. Currently, only the abstract has been released, indicating that this is an ADC molecule targeting Nectin-4, designed with MMAE and dual Topo1i as a triple payload. Below is the full abstract:Araris’s site-specific … Read more
Introduction: This article aims to discuss knowledge about TCP. Please forgive any inappropriate metaphors. In the fourth year of the Tianqi era of the Ming Dynasty, early morning. As dawn broke, I drove a horse-drawn cart full of goods to the South City Gate, which was the central location for handling goods. A line of … Read more