drug delivery

Applications of 3D Printing Technology in Medical Device Products

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The application of 3D printing technology in medical device products is rapidly expanding, evolving from early “model prototyping” to “final product manufacturing,” and exhibiting three major characteristics: “personalization, precision, and functionality.” The applications of 3D printing technology can be summarized into the following six major scenarios: 1. Personalized surgical models and navigation templates Using patient … Read more

After ADC, the ‘Bottlebrush’ ABC Has Arrived!

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After ADC, the 'Bottlebrush' ABC Has Arrived!

“Structure similar to a bottlebrush” In recent years, antibody-drug conjugates (ADCs) have emerged as a novel targeted therapy strategy, achieving precise targeting of cancer cells by covalently linking monoclonal antibodies with small molecule drugs. They have demonstrated good efficacy and safety in the treatment of various cancers. However, traditional ADCs still face many limitations in … Read more

Texas A&M Researchers Develop 3D Printed Medications for Children

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Texas A&M Researchers Develop 3D Printed Medications for Children

Researchers at Texas A&M University, led by Dr. Mansoor Khan, are advancing the application of 3D printing technology to produce medications specifically designed for children, addressing long-standing challenges in pediatric medication. By manufacturing dosage-flexible tablets, his approach ensures that children receive precise dosages that correspond to their age and weight, thus avoiding the need for … Read more

3D Printing Enhances the Efficiency of Asthma Inhalers

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3D Printing Enhances the Efficiency of Asthma Inhalers

For over 260 million asthma patients worldwide, inhalers are essential. However, studies show that 12–71% of cases involve improper use, with hospitalization rates as high as 86% for adults and even 97% for children, leading to a significant reduction in the actual dosage inhaled. Many patients face difficulties in using inhalers correctly, whether due to … Read more

Ultra-High Precision Micro-Scale 3D Printer: Printing Micron-Level Structures with Light Beams

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Ultra-High Precision Micro-Scale 3D Printer: Printing Micron-Level Structures with Light Beams

Editor’s Note Large scientific research instruments are powerful tools for achieving original breakthroughs in research, and open sharing has opened up new avenues for technological innovation. To promote the sharing and service level of large instruments at our university to a new height, allowing the investment in ‘instruments’ to ultimately demonstrate broader and greater effects … Read more

Bioinspired Hydrogel Actuator for Soft Robotics: Opportunities and Challenges

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Bioinspired Hydrogel Actuator for Soft Robotics: Opportunities and Challenges

Click the blue text above to subscribe (Image from Nano Today official website) Robotic technology is transforming industry and daily life. As an interdisciplinary field, robotics has garnered significant attention from mechanical engineering, computer science, materials science, chemistry, and other disciplines, facilitating the practical application of robots from micro/nano scales to macro scales. Traditional rigid … Read more

ADC Bioconjugation Technology

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ADC Bioconjugation Technology

Introduction The design of clinically successful ADCs depends not only on the potency of the payload and its attachment points, the stability of the linker, and effective drug release, but also on the choice of antibodies and bioconjugation technology. Over the past decade, all FDA-approved ADCs have existed in the form of heterogeneous mixtures of … Read more

Endocytosis Mechanism of ADC Drugs

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Endocytosis Mechanism of ADC Drugs

Introduction In addition to the need for ADCs to target antigens that are overexpressed in tumors, another important factor is the efficiency of endocytosis, which is necessary for the release of the drug’s active payload. In fact, the efficacy of ADCs depends on the efficiency of targeted-mediated internalization to deliver effective payloads within tumor cells. … Read more

Mechanisms of Endocytosis for ADC Drugs

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Mechanisms of Endocytosis for ADC Drugs

▲ Click the image for details PREFACE Introduction For Antibody-Drug Conjugates (ADCs), the selection of drug targets not only requires overexpression in tumors but also depends significantly on the efficiency of endocytosis, which is essential for drug release activity. In fact, the efficacy of ADCs relies on the efficiency of targeted-mediated internalization for delivering effective … Read more

Application Research of Microfluidic Loading and Immersion Sealing Technology in Microrobots for Drug Delivery

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Application Research of Microfluidic Loading and Immersion Sealing Technology in Microrobots for Drug Delivery

Click the blue text to follow us immediately The research was conducted by Rujie Sun and his team from Imperial College London, and the paper was published in the journal “Advanced Materials”. This study introduces a novel manufacturing technique for filling microrobots, known as Microfluidic Loading and Immersion Sealing (MLDS). This innovative approach aims to … Read more