Researchers at Texas A&M University, led by Dr. Mansoor Khan, are advancing the application of 3D printing technology to produce medications specifically designed for children, addressing long-standing challenges in pediatric medication. By manufacturing dosage-flexible tablets, his approach ensures that children receive precise dosages that correspond to their age and weight, thus avoiding the need for … Read more
For over 260 million asthma patients worldwide, inhalers are essential. However, studies show that 12–71% of cases involve improper use, with hospitalization rates as high as 86% for adults and even 97% for children, leading to a significant reduction in the actual dosage inhaled. Many patients face difficulties in using inhalers correctly, whether due to … Read more
Editor’s Note Large scientific research instruments are powerful tools for achieving original breakthroughs in research, and open sharing has opened up new avenues for technological innovation. To promote the sharing and service level of large instruments at our university to a new height, allowing the investment in ‘instruments’ to ultimately demonstrate broader and greater effects … Read more
Click the blue text above to subscribe (Image from Nano Today official website) Robotic technology is transforming industry and daily life. As an interdisciplinary field, robotics has garnered significant attention from mechanical engineering, computer science, materials science, chemistry, and other disciplines, facilitating the practical application of robots from micro/nano scales to macro scales. Traditional rigid … Read more
Introduction The design of clinically successful ADCs depends not only on the potency of the payload and its attachment points, the stability of the linker, and effective drug release, but also on the choice of antibodies and bioconjugation technology. Over the past decade, all FDA-approved ADCs have existed in the form of heterogeneous mixtures of … Read more
Introduction In addition to the need for ADCs to target antigens that are overexpressed in tumors, another important factor is the efficiency of endocytosis, which is necessary for the release of the drug’s active payload. In fact, the efficacy of ADCs depends on the efficiency of targeted-mediated internalization to deliver effective payloads within tumor cells. … Read more
▲ Click the image for details PREFACE Introduction For Antibody-Drug Conjugates (ADCs), the selection of drug targets not only requires overexpression in tumors but also depends significantly on the efficiency of endocytosis, which is essential for drug release activity. In fact, the efficacy of ADCs relies on the efficiency of targeted-mediated internalization for delivering effective … Read more
Click the blue text to follow us immediately The research was conducted by Rujie Sun and his team from Imperial College London, and the paper was published in the journal “Advanced Materials”. This study introduces a novel manufacturing technique for filling microrobots, known as Microfluidic Loading and Immersion Sealing (MLDS). This innovative approach aims to … Read more
Key Components and Mechanisms of ADC Stability The instability of linkers in the bloodstream (also known as premature payload release) is a major factor limiting the therapeutic index of ADCs. Stabilization technologies are strategies to improve the therapeutic window. If the drug cannot be linked to the ADC, it cannot be delivered directly to tumor … Read more
In the field of cancer immunotherapy, activating STING (Stimulator of Interferon Genes) is a key strategy to stimulate anti-cancer immune responses. STING, as an important innate immune protein, enhances anti-cancer immunity through type I interferon signaling. However, traditional STING agonists face numerous challenges during intravenous administration, such as short blood circulation half-life and insufficient tumor … Read more