Antibody Conjugates

In-Depth Analysis of ADCs: Part Two

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In-Depth Analysis of ADCs: Part Two

Introduction Antibodies are one of the key components of ADC drugs, serving as precise guiding components with the functions of targeting and toxin delivery. They can specifically recognize the target antigens on the surface of tumor cells, delivering toxins to the tumor cells and mediating the localization and endocytosis of ADCs in tumor cells[1]. After … Read more

Degrader-Antibody Conjugates: The Risky Path from Concept to Reality

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Degrader-Antibody Conjugates: The Risky Path from Concept to Reality

The Emergence and Advantages of DAC Cancer therapeutics need to achieve a balance between efficacy and safety, even targeted chemotherapy does not always only kill abnormal cancer cells, non-specific toxicity can lead to a low therapeutic index and side effects. The technology of proteolysis-targeting chimeras (PROTACs), which achieves therapeutic effects by promoting the degradation of … Read more