Payload The early developed ADCs used FDA-approved anticancer agent small molecule payloads, such as DM1 and vincristine, but these drugs have poor toxicity. Due to the large size of ADCs, it is estimated that only about 2% of ADCs are effectively internalized, thus more toxic payloads have been developed as ADC payloads, most of which … Read more
R-BINAP, R-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl 【(R)-(+)-2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl】 【CAS Number】76189-55-4 【Appearance】White powder S-BINAP, S-(-)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl 【(S)-(-)-2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl】 【CAS Number】76189-56-5 【Appearance】White powder In 1980, Noyori first synthesized BINAP and used it in chiral catalysis, demonstrating excellent enantioselectivity. Subsequently, BINAP and various metal (Ru, Pd, Ag, Rh, Ir, Au) complexes were continuously used in various reactions. Asymmetric hydrogenation reactions reduced aldehydes and ketones, used … Read more