MMAF

Following Successful Experiences: Payloads and Linkers of 14 Approved ADCs

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Following Successful Experiences: Payloads and Linkers of 14 Approved ADCs

The ADC Field Is Flourishing, with new technologies evolving like a raging torrent, propelling biomedicine into a sprint mode, this is the best of times. As early as the beginning of the 20th century, Paul Ehrlich first proposed the concept of the “magic bullet”, but the first ADC drug Mylotarg® (gemtuzumab ozogamicin) was not approved … Read more

ADC Drug Payload Series (Part 2): Microtubule Protein Inhibitor Auristatin

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ADC Drug Payload Series (Part 2): Microtubule Protein Inhibitor Auristatin

ADC Drug Payload Series (Part 2): Microtubule Protein Inhibitor Auristatin Introduction In the previous article, we detailed one of the most widely used microtubule protein inhibitors in ADC drugs: Maytansinoids (see original text). Today, we will continue to explore another class of microtubule protein inhibitors that occupies a significant portion of ADCs—Auristatin. These molecules also … Read more