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ASCENT-04 Study: TROP2 ADC SG Combined with Keytruda Establishes New First-Line Standard for PDL1+ Triple-Negative Breast Cancer

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ASCENT-04 Study: TROP2 ADC SG Combined with Keytruda Establishes New First-Line Standard for PDL1+ Triple-Negative Breast Cancer

The ASCENT-04 study is a global, multicenter, randomized, open-label phase III clinical trial designed to evaluate the efficacy and safety of the TROP2-targeted antibody-drug conjugate (ADC) sacituzumab govitecan (SG) combined with the PD-1 inhibitor pembrolizumab (Keytruda, K drug) compared to chemotherapy combined with K drug in first-line treatment of PD-L1 positive (CPS≥10) metastatic triple-negative breast … Read more

Precise Coupling Mechanism of ADC Linkers and Crosslinkers: Targeted Release and Structural Regulation

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Precise Coupling Mechanism of ADC Linkers and Crosslinkers: Targeted Release and Structural Regulation

Linkers N – hydroxysulfosuccinimide sodium salt,FL-TPD and others possess high reactivity and cleavable characteristics, allowing them to specifically bind to antibodies and drug molecules under mild conditions, forming stable connections. In specific in vivo environments, linkers can precisely release drugs, ensuring the targeted action of ADC drugs. Protein crosslinkers such as glutaraldehyde and azide– PEG … Read more

Overview of DWI and ADC Values in MRI

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Overview of DWI and ADC Values in MRI

MRI is a noninvasive medical imaging test that uses magnets and radio waves to create detailed images of almost every internal structure in the body. The core components of MRI include: Main Magnetic Field, in the most common cylindrical (closed) MRI devices, the direction of B₀ is parallel to the long axis of the examination … Read more

How to Apply ADC Coupling Strategies to Antibody-Conjugated LNPs?

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How to Apply ADC Coupling Strategies to Antibody-Conjugated LNPs?

The success of ADCs (Antibody-Drug Conjugates) relies on the continuous evolution of three generations of coupling technologies. From the “coarse” non-specific coupling to the “precise” gene-engineered modifications, and then to the “efficient” natural antibody modifications. Today, this iterative logic is providing key insights for breakthroughs in targeted delivery of antibody-conjugated LNPs (Ab-LNP).Ab-LNP requires precise coupling … Read more

Overview of ADC Conjugation Technology

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Overview of ADC Conjugation Technology

–01– Introduction For decades, advancements in antibody-drug conjugates (ADC) and bioconjugates have revolutionized targeted therapies for various diseases. Unlike traditional chemotherapy, ADCs selectively target tumor cells while sparing normal cells, making them highly suitable for cancer treatment. Currently, there are 17 types of ADCs approved by regulatory agencies in different countries worldwide. Over 200 more … Read more

Resolution and Accuracy of ADCs

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Resolution and Accuracy of ADCs

Today, we will discuss a concept in electronics that is often confused: the resolution of an Analog-to-Digital Converter (ADC) and its accuracy. Although these two terms sound similar, they represent vastly different meanings, much like a ruler where fine markings do not guarantee accurate measurements! 1. Resolution of ADC (Resolution): Similar to the smallest scale … Read more

Design of a Digital Voltmeter Based on FPGA and LTC2308 – Interpretation of LTC2308 Datasheet

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Design of a Digital Voltmeter Based on FPGA and LTC2308 - Interpretation of LTC2308 Datasheet

1 Introduction The LTC2308 is a low-noise, 12-bit high-precision, successive approximation, 8-channel analog-to-digital converter (ADC) from Analog Devices Inc. (ADI), with a sampling rate of up to 500 kSPS (the maximum input signal frequency should not exceed 500 kHz; according to the Nyquist sampling theorem, it is recommended that the input signal be below 250 … Read more

Embedded Sharing #36: RK3576 Flashing Failure? A Step-by-Step Guide to Troubleshoot Core Issues

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Embedded Sharing #36: RK3576 Flashing Failure? A Step-by-Step Guide to Troubleshoot Core Issues

Cover Image The Yuan Dynasty capital, Shangdu, located in the Inner Mongolia grasslands, has a history of about 750 years, predating the capital’s establishment in Beijing. It was here that Marco Polo first met Kublai Khan, the founder of the Yuan Dynasty. Main Content When encountering a system that cannot be flashed during board-level debugging, … Read more

New Antitumor Drug – PDL1 ADC

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New Antitumor Drug - PDL1 ADC

Antibody-drug conjugates (ADCs) in antitumor therapy, also known as “biological missiles,” are a new type of drug that combines targeting and antitumor activity. By linking cytotoxic drugs to targeted drugs, when the targeted drug acts on the corresponding target, the drug enters the tumor cells through phagocytosis, causing lysis and releasing the cytotoxic drug to … Read more

Insights on ADC Learning Experience (250823)

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Insights on ADC Learning Experience (250823)

This week’s exercises were mainly focused on exercise6.8 which got me stuck. Initially, I followed the author’s approach and derived the formula for a long time, but later realized that the formula was too complex to yield specific values. After getting stuck, I paused for a few days, and when I picked it up again … Read more