Choosing ADC Toxins: IC50, Mechanisms, and Clinical Insights
Author｜Wenxin Small molecule cytotoxins serve as the “warheads” for ADCs and are crucial components in killing tumor cells. Although there are numerous toxins derived from natural products and chemical synthesis, only a small fraction can be used as cytotoxins in ADCs. The reason is that ADCs have high requirements for toxins, which typically must meet … Read more