tumor targeting

Another Bright Path for ADC Development – Non-Internalizing ADC

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Another Bright Path for ADC Development - Non-Internalizing ADC

Antibody-Drug Conjugates (ADC) typically require internalization to release their cytotoxic payload. However, there are strict limitations, requiring high expression of internalizing antigens and efficient intracellular processing. A new method has emerged, allowing the payload to be released extracellularly from cleavable linkers after binding to poorly internalizing antigens or other tumor components. This method eliminates the … Read more

ADC Technology Report: Predicting The Future Of Next-Generation ADCs

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ADC Technology Report: Predicting The Future Of Next-Generation ADCs

Source: Beike Society Antibody-drug conjugates (ADCs) have become a popular avenue in tumor treatment in recent years, typically covalently linking a monoclonal antibody (mAb) to a cytotoxic drug (payload) via a chemically synthesized linker. ADCs combine the advantages of highly specific targeting capabilities with potent killing effects, achieving precise and efficient elimination of cancer cells. … Read more

Mechanisms of Endocytosis for ADC Drugs

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Mechanisms of Endocytosis for ADC Drugs

▲ Click the image for details PREFACE Introduction For Antibody-Drug Conjugates (ADCs), the selection of drug targets not only requires overexpression in tumors but also depends significantly on the efficiency of endocytosis, which is essential for drug release activity. In fact, the efficacy of ADCs relies on the efficiency of targeted-mediated internalization for delivering effective … Read more

Selection of Target Antigens in ADC Design

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Selection of Target Antigens in ADC Design

Source: Xiaoyao Shuo Yao Introduction Antibody-drug conjugates (ADC) are a powerful cancer treatment method that combines monoclonal antibodies targeting specific antigens with small molecule cytotoxic drugs linked by a linker. ADCs utilize the specificity of antibodies for their target antigens, combined with the potency of cytotoxic drugs, to selectively kill tumor cells expressing the target … Read more

The Dual Role of Protein Corona in Tumor Targeting, Immunotherapy, and Diagnosis

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The Dual Role of Protein Corona in Tumor Targeting, Immunotherapy, and Diagnosis

Recently, Associate Professor Zhang Wenli’s team at China Pharmaceutical University published a review titled “The Janus of Protein Corona on Nanoparticles for Tumor Targeting, Immunotherapy and Diagnosis” in Journal of Controlled Release, Volume 345, 2022, and it was selected as the Inside Back Cover article of that issue.. Figure 1. The dual-edged effect of protein … Read more