Microtubule Inhibitors

Choosing ADC Toxins: IC50, Mechanisms, and Clinical Insights

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Choosing ADC Toxins: IC50, Mechanisms, and Clinical Insights

Author｜Wenxin Small molecule cytotoxins serve as the “warheads” for ADCs and are crucial components in killing tumor cells. Although there are numerous toxins derived from natural products and chemical synthesis, only a small fraction can be used as cytotoxins in ADCs. The reason is that ADCs have high requirements for toxins, which typically must meet … Read more

ADC Drug Payload Series (Part 2): Microtubule Protein Inhibitor Auristatin

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ADC Drug Payload Series (Part 2): Microtubule Protein Inhibitor Auristatin

ADC Drug Payload Series (Part 2): Microtubule Protein Inhibitor Auristatin Introduction In the previous article, we detailed one of the most widely used microtubule protein inhibitors in ADC drugs: Maytansinoids (see original text). Today, we will continue to explore another class of microtubule protein inhibitors that occupies a significant portion of ADCs—Auristatin. These molecules also … Read more