The Metabolism Process of ADC The in vivo delivery process of the payload is complicated due to the complex structure of ADCs and their metabolic degradation in the body. After ADC administration, the Drug-to-Antibody Ratio (DAR), bound or free antibodies, albumin conjugates, free payloads, and payload metabolites are all in a highly dynamic state over … Read more
The development of next-generation ADC drugs has gradually shifted towards the development of new toxins and linkers as foundational technologies. Multi-antibody or multi-toxin approaches have become a new trend. Following Araris and Puzhong’s advancements in tri-toxin and hexatozin,Aarvik has now introduced quadruple antibody-drug conjugates (ADCs). Aarvik may not have a prominent reputation in the ADC … Read more
Key Components and Mechanisms of ADC Stability The instability of linkers in the bloodstream (also known as premature payload release) is a major factor limiting the therapeutic index of ADCs. Stabilization technologies are strategies to improve the therapeutic window. If the drug cannot be linked to the ADC, it cannot be delivered directly to tumor … Read more
–01– Introduction The announcement of the 2022 Nobel Prize in Chemistry brought the cutting-edge technology of “Click Chemistry” into the public eye. The groundbreaking work of three scientists has not only revolutionized the field of organic synthesis but also opened new pathways for cancer treatment—specifically, the development of Antibody-Drug Conjugates (ADC) is advancing towards a … Read more
Xinge Corporation (headquartered in Nagoya, Aichi Prefecture, Japan) recently announced that non-clinical data for its novel antibody-drug conjugate (ADUC) K-679 will be officially presented at the American Association for Cancer Research (AACR) Annual Meeting 2025, scheduled to take place from April 25 to 30, 2025, in Chicago, Illinois, USA. K-679 K-679 is an antibody-drug conjugate … Read more
Introduction As one of the most active innovative drug development areas at present, Antibody-Drug Conjugates (ADCs) are rising at an astonishing pace. The global industry interest continues to heat up, with ADC innovative drugs being approved one after another. As of March 2025, a total of 17 ADC products have been approved for market release … Read more
Follow Xiaobai Learning Medicine As of now, 17 ADC drugs have been approved worldwide, of which 5 ADCs are coupled with lysine. Table 1 Summary of ADC Drugs Coupled with Lysine Approved Product Name Company Target DAR Toxin Linker Antibody Type Payload Type Mylotarg Pfizer CD33 2~3 Calicheamicin Hydrazone Link (Acid-labile) IG4 DNA Damaging Agent … Read more
AI Summary The patient had platinum-resistant ovarian cancer with multiple treatment failures, presenting with liver, lymph node, and bone metastases, and conventional treatments were ineffective. After using the novel targeted drug RC88, significant shrinkage of liver metastases and hilar lymph nodes was observed, with a reduction in the extent of bone metastases, achieving partial remission. … Read more
The AACR is always bustling every year, and this year I am particularly focused on the progress of dual payload ADCs. I have written several articles on this topic before, and just a few days ago, I was discussing with my supervisor that “I haven’t seen any dual payload ADCs advancing to clinical trials yet,” … Read more
Written by Wang Cong Edited by Wang Duoyu Formatted by Shui Chengwen Breast cancer has the highest incidence rate among malignant tumors in women, thus it is referred to as the “pink killer.” According to the global cancer burden data released by the International Agency for Research on Cancer (IARC) in 2020, breast cancer has … Read more