Special Reminder Due to adjustments in the WeChat public account mechanism, please click on the top “Instrument Information Network” → the upper right “…” → set as★ a star, otherwise you may not see our updates. On June 12, XtalPi Technology (XtalPi Holdings, 2228.HK) announced the completion of its acquisition of the UK-based LiverpoolChiroChem (LCC) … Read more
Click the blue text Follow us This Issue Focus Point B7-H4 is a member of the B7 immune checkpoint ligand family, which has been shown to bind to an unknown receptor on T cells, inhibiting T cell proliferation and cytokine production, thereby negatively regulating T cell function. The expression level of B7-H4 is elevated in … Read more
Not all long-established ADC Biotechs can achieve a successful exit like Seagen (Seattle Genetics). Today, Mersana Therapeutics, a 23-year-old veteran biotech, has reached its most desperate moment. With a cumulative deficit of $900 million and only $134.6 million left in cash, its two core pipeline products are still in Phase I clinical trials. To sustain … Read more
Click the “blue text” to follow us Every year, millions of patients worldwide are waiting for organ transplants, but there is a severe shortage of donated organs. Statistics show that in the United States alone, about 20 people die each day waiting for a suitable organ. Faced with this dilemma, scientists have proposed a bold … Read more
In the pharmaceutical industry, there is a “double ten law”: the average cost of developing an innovative drug from initiation to market exceeds $1 billion, takes more than 10 years, and about 90% of drugs fail during clinical trials. Hong Kong-listed JingTai Technology is reshaping the productivity paradigm of drug development through technological transformation: the … Read more
Expert Forum Authors: Xue Jiaohao1, Li Zhipeng1, Zhao Yuanli2 Affiliations: 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 2Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Corresponding Author: Zhao Yuanli Funding Project: Central High-Level Hospital Clinical Research Special Project (2023-PUMCH-E-011) Source: Chinese Journal of Medicine, 2025, 16(2): 277-284. Cerebrovascular … Read more
Introduction As one of the most active innovative drug development areas at present, Antibody-Drug Conjugates (ADCs) are rising at an astonishing pace. The global industry interest continues to heat up, with ADC innovative drugs being approved one after another. As of March 2025, a total of 17 ADC products have been approved for market release … Read more
Follow Xiaobai Learning Medicine As of now, 17 ADC drugs have been approved worldwide, of which 5 ADCs are coupled with lysine. Table 1 Summary of ADC Drugs Coupled with Lysine Approved Product Name Company Target DAR Toxin Linker Antibody Type Payload Type Mylotarg Pfizer CD33 2~3 Calicheamicin Hydrazone Link (Acid-labile) IG4 DNA Damaging Agent … Read more
The AACR is always bustling every year, and this year I am particularly focused on the progress of dual payload ADCs. I have written several articles on this topic before, and just a few days ago, I was discussing with my supervisor that “I haven’t seen any dual payload ADCs advancing to clinical trials yet,” … Read more
If a few years ago, presenting a simple PowerPoint on the ADC field could impress without the need for future visions, cutting-edge technologies, or a vibrant pipeline forest, today, the ADC field requires substantial content to make an impact. This shift is attributed to advancements in industry technology and rising awareness. Data shows that from … Read more