Global Analysis of ADC Drugs: Popular, Emerging Targets and Star Drugs The human epidermal growth factor receptor2 (HER2) is one of the most extensively studied and fruitful targets in ADC drugs.HER2 belongs to the ERBB receptor tyrosine kinase family and is overexpressed or amplified in various epithelial-derived tumors, including breast cancer, gastric cancer, and non-small … Read more
Antibody-drug conjugates (ADCs) are a class of biotherapeutic drugs targeting cancer, combining the targeting capability of monoclonal antibodies (mAbs) with the anticancer efficacy of cytotoxic drugs (Payload). The antibody and payload are linked by a linker, allowing specific drugs to be delivered to cancer cells targeted by the antibody. Once inside the cell, the linked … Read more
The purpose of testing liver function is to detect any damage to the liver, determine the cause, assess prognosis, and differentiate jaundice. Therefore, the clinical application of liver function tests is of significant value in diagnosis, treatment, and prognosis. There are many types of liver function tests, numbering in the hundreds, but each test can … Read more
Please click the “Bio New Thinking” above to follow for more exciting content! Introduction With the continuous improvement of biopharmaceutical research and clinical research levels, the research and application of Antibody-Drug Conjugates (ADCs) have been increasing. ADCs are mainly composed of antibodies, linkers, and small molecule toxins, combining high targeting specificity with high cytotoxicity. However, … Read more
Click the blue text to follow us With the advent of biomarker-guided personalized targeted therapies and immune checkpoint inhibitors, the treatment of non-small cell lung cancer (NSCLC) continues to undergo transformation. Recently, antibody-drug conjugates (ADCs) have brought revolutionary new hope, such as trastuzumab-deruxtecan (T-DXd) being used for previously treated HER2 (ERBB2) mutated advanced NSCLC, which … Read more
Author | Xiao Yu Periodically, major pharmaceutical media and authoritative journals summarize the development of Antibody-Drug Conjugates (ADCs). Recently, a review on ADCs published by the internationally renowned journal ACS was particularly eye-catching. As a member of CAS (a division of the American Chemical Society), Janet M. Sasso’s team innovatively utilized patents and articles related … Read more
MedRobot updates the latest developments of global surgical robot companies daily, welcome to follow! 01 Technical Concept From the perspective of technological development, as a “technology”, the initial concept of surgical robots is CAS. Computer Assisted Surgery (CAS): represents a surgical concept and set of methods that use computer technology for preoperational planning and for … Read more
Introduction Antibody-drug conjugates (ADC) therapy has rapidly developed over the past few decades, with 14 products approved globally and over 140 ADCs currently in clinical trials. By 2030, the ADC market is expected to exceed $15 billion. The basic principle of ADCs is that by combining the specificity of monoclonal antibodies with the cytotoxicity of … Read more
Antibody-Drug Conjugates (ADC) typically require internalization to release their cytotoxic payload. However, there are strict limitations, requiring high expression of internalizing antigens and efficient intracellular processing. A new method has emerged, allowing the payload to be released extracellularly from cleavable linkers after binding to poorly internalizing antigens or other tumor components. This method eliminates the … Read more
Follow+Star Public Number, Don’t Miss Exciting Content Editor | strongerHuang WeChat Public Account | Embedded Column The principle of an oscilloscope is simply an ADC conversion, which displays the collected different voltages on the screen. Today, we will discuss what the oscilloscope sampling rate is all about. Example Describing Sampling Rate 1. Storage Depth Imagine … Read more