In 1913, H.J. Bagg from the National Cancer Institute in the United States bred the “Bagg albino” from a white original strain; in 1923, Mac Dowell conducted inbreeding; and in 1932, the 26th generation was obtained and named the BALB/c strain.The BALB/c mouse is difficult to distinguish from the “ICR” and “NIH” mice, all having … Read more
Introduction Antibody-drug conjugates (ADC) therapy has rapidly developed over the past few decades, with 14 products approved globally and over 140 ADCs currently in clinical trials. By 2030, the ADC market is expected to exceed $15 billion. The basic principle of ADCs is that by combining the specificity of monoclonal antibodies with the cytotoxicity of … Read more
Antibody Drug Conjugates (ADCs) are a new type of targeted anti-tumor therapy. They combine the targeting capability of monoclonal antibodies with the cytotoxic effects of highly effective chemotherapeutic agents, primarily used for the treatment of various refractory cancers. ADCs precisely identify and attack cancer cells while minimizing damage to normal cells, thus exhibiting high efficiency … Read more
The human epidermal growth factor receptor 2 (HER2) is a known important molecular target in breast cancer. As one of the proto-oncogenes, HER2 is often associated with aggressiveness, recurrence, metastasis, and poor prognosis. The clinical application of the anti-HER2 drug trastuzumab has significantly improved the diagnosis and treatment patterns and prognosis of HER2-positive breast cancer, … Read more
The history of medicine is a process of “Shennong tasting hundreds of herbs”. Aside from daily experiments, many groundbreaking advances and discoveries are often accidental. As spring arrives, more friends around me are sneezing and coughing. Most people will buy antibiotics like cephalosporins at the slightest cough or runny nose, but are antibiotics really effective … Read more
“This article is for medical professionals only” As the application of biologics in psoriasis continues to become widespread, have you had such experiences in your clinical work? “Early patients show significant clinical efficacy when using biologics, but over time, a certain proportion of patients always exhibit a decline in efficacy?” What is behind this? Let’s … Read more
In the early 20th century, Paul Ehrlich first proposed the famous “magic bullet” theory, suggesting that drugs could be developed to specifically target pathogens without affecting normal tissues and cells. Subsequently, the concept of antibody-drug conjugates (ADCs) was introduced, combining the target specificity of monoclonal antibodies with the anti-tumor properties of cytotoxic molecules. After decades … Read more