Antibody Drug Conjugates

Literature Sharing | J AM CHEM SOC | Probiotic-Drug Conjugates Achieve Site-Specific Probiotic Colonization and On-Demand Drug Release to Combat Ulcerative Colitis and Its Complications

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Literature Sharing | J AM CHEM SOC | Probiotic-Drug Conjugates Achieve Site-Specific Probiotic Colonization and On-Demand Drug Release to Combat Ulcerative Colitis and Its Complications

1. Research Background Ulcerative colitis (UC) is a chronic intestinal disease that severely affects the quality of life of patients and significantly increases the risk of colorectal cancer (CAC) associated with colitis, posing a major threat to patient survival. Current treatment strategies for UC are limited by single therapeutic mechanisms, uncontrolled drug release, and non-specific … Read more

Global Landscape of ADCs from a God’s Eye View

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Global Landscape of ADCs from a God’s Eye View

Author | Xiao Yu Periodically, major pharmaceutical media and authoritative journals summarize the development of Antibody-Drug Conjugates (ADCs). Recently, a review on ADCs published by the internationally renowned journal ACS was particularly eye-catching. As a member of CAS (a division of the American Chemical Society), Janet M. Sasso’s team innovatively utilized patents and articles related … Read more

Another Domain of Drug Conjugation: PDC

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Another Domain of Drug Conjugation: PDC

IDC2023 Fifth Chemical Innovation Drug and Small Molecule Conjugate Drug R&D Forum is coming with 10 major sections over 2 days, 80+ Speakers and 1200 guests gathering in Suzhou to discuss: chemical innovation drugs, modified new drugs, ADCs, small molecule conjugates, peptide conjugates, and more. Cooperation hotline: Li Xinxin 15800452389. Click the image to view … Read more

DAC: Degrader-Antibody Conjugates and Their Mechanisms

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DAC: Degrader-Antibody Conjugates and Their Mechanisms

Introduction Degrader-antibody conjugates (DAC) are a novel entity that combines the payload of a proteolysis-targeting chimera (PROTAC) with monoclonal antibodies through a type of chemical linker (DAC = PROTAC + ADC). This article collects several examples of DAC from scientific and patent literature and records specific challenges associated with DAC construction. Overall, these examples indicate … Read more

Understanding ADC Drugs: Side Effects and Management

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Understanding ADC Drugs: Side Effects and Management

Click below to follow and never miss cancer knowledge~ Author: Guo Lin When it comes to cancer treatment, chemotherapy, surgery, and radiotherapy are the most familiar traditional methods. However, with the advancement of anti-cancer technology, a new type of “smart” anti-cancer drug that combines the advantages of chemotherapy and targeted drugs—Antibody Drug Conjugates (ADC)—has gradually … Read more