Drug Design

Key Considerations in ADC Design Based on Pharmacokinetics

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Key Considerations in ADC Design Based on Pharmacokinetics

Please click the “Bio New Thinking” above to follow for more exciting content! Introduction With the continuous improvement of biopharmaceutical research and clinical research levels, the research and application of Antibody-Drug Conjugates (ADCs) have been increasing. ADCs are mainly composed of antibodies, linkers, and small molecule toxins, combining high targeting specificity with high cytotoxicity. However, … Read more

Design Mechanisms and Adverse Reaction Management of Antibody-Drug Conjugates (ADCs)

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Design Mechanisms and Adverse Reaction Management of Antibody-Drug Conjugates (ADCs)

Introduction: Antibody-drug conjugates (ADC) consist of antibodies, linkers, and small molecule cytotoxic drugs, combining high specificity and high cytotoxicity advantages. However, their structural diversity and complexity, along with the low content of released small molecule toxins in the circulatory system, pose significant challenges for pharmacokinetic studies. This article will discuss the mechanisms, design, safety features, … Read more