Biotechnology

The Evolution of Antibody-Drug Conjugates (ADCs): Opportunities and Challenges

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The Evolution of Antibody-Drug Conjugates (ADCs): Opportunities and Challenges

At this year’s AACR annual meeting, there were hundreds of details related to ADC drugs. Leading ADC company Daiichi Sankyo announced the latest research progress of its HER3-targeted ADC product Patritumab deruxtecan (HER3-DXd); AstraZeneca also disclosed research updates on several drugs including AZD9592 (bispecific ADC) and AZD5335 (FRα ADC). Many Chinese pharmaceutical companies also showcased … Read more

These Two Companies’ ADC Products Ride the Wave of Global PD-1 Sales Champions, Why Worry About Future Sales?

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These Two Companies' ADC Products Ride the Wave of Global PD-1 Sales Champions, Why Worry About Future Sales?

We previously mentioned that the current standard treatment for cancer is gradually shifting from PD-1 + chemotherapy to PD-1 + ADC drugs. According to relevant data, the global ADC drug market size has grown from $7.9 billion in 2022 to approximately $20 billion in 2024, showing strong growth momentum. Among them, DS8201 (HER2 ADC), jointly … Read more

The Predicament of Established ADC Biotech

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The Predicament of Established ADC Biotech

Not all long-established ADC Biotechs can achieve a successful exit like Seagen (Seattle Genetics). Today, Mersana Therapeutics, a 23-year-old veteran biotech, has reached its most desperate moment. With a cumulative deficit of $900 million and only $134.6 million left in cash, its two core pipeline products are still in Phase I clinical trials. To sustain … Read more

Nanotechnology Sensors: Key to Winning Intelligent Warfare

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Nanotechnology Sensors: Key to Winning Intelligent Warfare

The birth of nanotechnology sensors has propelled human society into the era of intelligent sensors. It integrates numerous excellent properties, providing important diversified means for detecting the microscopic world at the nanoscale, which will trigger a revolutionary impact in the military field. It is the nanotechnology sensor. So, what is a nanotechnology sensor? What are … Read more

Comprehensive Overview of ADC Drug Development

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Comprehensive Overview of ADC Drug Development

What Is ADC? Antibody-drug conjugates (ADC) are a new type of targeted therapeutic drug, composed of monoclonal antibodies that specifically target antigens linked to small molecule cytotoxic drugs via linkers. They combine the powerful killing effect of traditional small molecule chemotherapy with the tumor-targeting capability of antibody drugs. This structure allowsADC to deliver drugs directly … Read more

Exploring Tiny Robots Within the Human Body

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Exploring Tiny Robots Within the Human Body

In the 1966 American science fiction film “Fantastic Voyage,” several American doctors shrink a submarine to a size smaller than a red blood cell and send it through blood vessels into the brain to clear a clot blocking the brain, ultimately saving a scientist’s life. From this film, we can see that the concept of … Read more

Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection

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Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection

◆ ◆ ◆ ◆ Sci Adv | Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection Technological innovation is a crucial engine for modern life sciences research. Each iteration and update of biotechnology brings disruptive changes to the life sciences field. In recent years, single-cell sequencing technology has developed rapidly, propelling scientists worldwide … Read more

Nanobodies: A New Generation of Antibodies

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Nanobodies: A New Generation of Antibodies

Nanobodies（Nanobody, Nbs） are a new member of the antibody family, characterized by their relatively small molecular weight, ease of humanization, high affinity, high stability, microbial expression capability, low immunogenicity, strong penetration ability, and good solubility. They have attracted significant attention in basic medical research as well as disease diagnosis and treatment. Introduction to Nanobodies 1. … Read more

Small Yet Beautiful Wearable Medical/Health Devices

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Small Yet Beautiful Wearable Medical/Health Devices

Note: 1. This article mainly collects some POC-related medical/health monitoring device technology companies and their main products. 2. A senior from Kun Yuan Gene once asked what kind of data has scientific significance, and the key word from the senior was “background”. 3. Taking the recent Verily 10,000-person project (projectbaseline.com) as an example (note: assuming … Read more

3D Printing Living Materials With Programmable Ink

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3D Printing Living Materials With Programmable Ink

A concept validation study published in Nature Communications reported on a programmable microbial ink for 3D printing of living materials produced from genetically engineered protein nanofibers. This study demonstrated the potential applications of this technology, such as isolating toxic chemicals like bisphenol A (BPA) that appear in the environment. By directly utilizing microorganisms to prepare … Read more