Mechanisms of Non-Targeted Uptake and Toxicity of ADC Drugs

Mechanisms of Non-Targeted Uptake and Toxicity of ADC Drugs

1 Introduction Antibody-drug conjugates (ADCs) are a new type of highly effective biopharmaceuticals that link antibodies with biologically active small molecule cytotoxic payloads through linkers. ADCs are designed to improve the therapeutic index (TI) of chemotherapeutic agents by selectively delivering cytotoxic drugs to tumor cells while reducing exposure in normal cells. Despite using a large … Read more

Controlling Xiaomi Micro Motor with STM32 HAL Library

Controlling Xiaomi Micro Motor with STM32 HAL Library

Previously, due to the robot dog project, I had been using the Xiaomi micro motor, but I struggled to find a detailed tutorial, encountering many pitfalls while learning to control the motor. Today, we will implement the control of the Xiaomi micro motor step by step using buttons. This article will analyze the Xiaomi motor … Read more

Platinum(IV)-Backboned Polymer Prodrug-Functionalized Manganese Oxide Nanoparticles for Enhanced Lung Cancer Chemoimmunotherapy

Platinum(IV)-Backboned Polymer Prodrug-Functionalized Manganese Oxide Nanoparticles for Enhanced Lung Cancer Chemoimmunotherapy

iNature The stimulator of interferon genes (STING) pathway shows great potential in reshaping the immunosuppressive tumor microenvironment and initiating anti-tumor immunity. However, effectively activating STING while avoiding toxic side effects from systemic administration remains challenging. On January 7, 2025, a communication from Li Weimin’s team at Sichuan University was published online in ACS Nano titled … Read more

Communication and Storage Technologies for Advanced Autonomous Driving Systems

Communication and Storage Technologies for Advanced Autonomous Driving Systems

Advanced autonomous vehicles require high-bandwidth and low-latency networks to connect all sensors, cameras, diagnostic tools, communication systems, and central artificial intelligence. These technologies generate, send, receive, store, and process vast amounts of data. For the next generation of autonomous driving domain controllers, commonly used in-vehicle networks include CAN, LIN, FlexRay, MOST, and LVDS. Except for … Read more

Understanding Automotive CAN Bus Technology Principles

This article is reprinted from the Jishu Community Jishu Column: Shanghai Hangxin Author: C H E N Y I With the continuous development of the automotive industry, the number of automotive electronic control units has gradually increased, and the signal exchange between various control units has become more complex. The CAN bus connects the various … Read more

Hands-On UDS Diagnostics Using STM32 Development Board

Hands-On UDS Diagnostics Using STM32 Development Board

1 Introduction UDS (Unified Diagnostic Services) is a very important diagnostic protocol in vehicles. However, unless you can access an actual project, I have not seen any open-source boards that can perform real UDS diagnostics; purely discussing theory is not very interesting. I bought a set of UDS_bootloader source code on Xianyu. Currently, I have … Read more

The Evolution of Automotive LIN Bus Technology

The Evolution of Automotive LIN Bus Technology

Yesterday, I shared an article titled “The Evolution of Automotive CAN Bus,” which sparked a lot of interest among friends, prompting them to leave messages asking for related knowledge about the LIN bus used in automobiles. Thus, I am sharing this article titled “The Evolution of Automotive LIN Bus” with everyone. I have modified the … Read more

How Many Types of Buses Are There? Why Do Engineers Often Get Confused?

How Many Types of Buses Are There? Why Do Engineers Often Get Confused?

First, it should be understood what a bus is. According to Baidu’s complete definition: a bus is a common communication line for transmitting information between various functional components of a computer, composed of wire transmission lines, classified according to the types of information transmitted by the computer. In fact, a bus is an internal structure … Read more

25 Lectures on Bus: A Fully Automated OTA Testing Method

25 Lectures on Bus: A Fully Automated OTA Testing Method

Absolute Content OTA is the star of the automotive electronics field, there is hardly any technical direction more popular and imaginative than it. Itis both useful and impressive, a typical business that has both substance and appearance, can serve both as a façade and a solid platform. Excellent companiescan charge for value-added services using OTA, … Read more

Exploring Time Synchronization in CAN Tools

Exploring Time Synchronization in CAN Tools

This matter really shocked me. Once upon a time, when I opened CANoe, I really thought the following prompt was nonsense; Vector was just being overly cautious. Until one day, I felt that this matter might not be so simple and worth pondering. A very simple example is our country’s BeiDou system, which has put … Read more