Patients with cholangiocarcinoma (BTC) have a very poor prognosis. In recent years, both the incidence and mortality rates have shown a continuous upward trend. BTC mainly includes gallbladder cancer (GBC) and cholangiocarcinoma (CCA), which can be broadly divided into two subtypes: intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC). It is well known that clarifying the … Read more
Editor’s Note On May 11, at the 18th Gastric Cancer Academic Conference (CGCC 2024), Professor Ying Jie’Er from Zhejiang Provincial Cancer Hospital delivered an academic report titled “Treatment of Elderly Patients with Advanced Gastric Cancer”. The content is organized as follows for readers. 1. Epidemiology and Prognosis of Elderly Patients with Advanced Gastric Cancer According … Read more
Antibody-drug conjugates (ADCs) have become a popular avenue in tumor treatment in recent years, typically covalently linking monoclonal antibodies (mAbs) with cytotoxic drugs (payloads) via chemically synthesized linkers. ADCs combine the advantages of highly specific targeting capabilities and effective killing actions, achieving precise and efficient clearance of cancer cells.Figure 1. Structure and characteristics of ADC … Read more
Let’s take a moment to focus on the recent hot topic of Antibody–Drug Conjugates and systematically learn about the review published in Cancers: Antibody–Drug Conjugates for the Treatment of Breast Cancer. Abstract Currently, aside from endocrine therapy and targeted drugs, the common treatment method for metastatic breast cancer (BC) is chemotherapy. However, the lack of … Read more
This article is compiled from Professor Song Zhengbo of Zhejiang Provincial Cancer Hospital.“Current Status and Development Challenges of ADC Drugs”. Song Zhengbo Doctor of Oncology, Associate Chief Physician, Associate Professor, Master’s Supervisor More than 100 years ago, the father of immunology, Paul Ehrlich, first proposed the concept of “magic bullet,” which refers to selectively delivering … Read more
1. Overview Antibody-drug conjugates (ADCs) rejuvenate the concept of targeted chemotherapy by coupling cytotoxic payloads to antibodies. The first stage of the complex intracellular toxin delivery process of ADCs is endocytosis. Analyzing the endocytic action of target receptors and ADCs can greatly advance preclinical research, clinical translation, and patient treatment outcomes. The in vitro efficacy … Read more
ADCs are currently the trending molecules, sweeping across the globe, with 15 ADC drugs approved for market entry worldwide, and hundreds more under development. Various BD transactions continuously stimulate interest, and these phenomena precisely illustrate the future prospects of ADCs. BD Overview According to incomplete statistics, in the first quarter of 2024, there were 10 … Read more
Click on the above “Peking University Tumor Hepatobiliary Surgery One” to subscribe Presenter: Dr. Wang Hongwei Consultation Time: Friday Afternoon Report Title Controversies in Lymph Node Dissection for Intrahepatic Cholangiocarcinoma Intrahepatic cholangiocarcinoma (ICC) refers to a malignant tumor originating from the epithelial cells of the intrahepatic bile ducts, particularly the secondary bile ducts and above. … Read more
The Journal of Neurosurgery was published online on February 4, 2022, by 15 experts from the USA, Turkey, Egypt, Czech Republic, India, Dominican Republic, Canada, and others, including Stylianos Pikis, Georgios Mantziaris, Selcuk Peker, titled “Stereotactic radiosurgery for intracranial chordomas: an international multiinstitutional study” (doi: 10.3171/2021.12.JNS212416). Objective: The aim of this study is to evaluate … Read more
Diffuse Large B-Cell Lymphoma: Composed of centroblastic (non-cleaved), B immunoblastic, and anaplastic large B-cell lymphomas classified by Kiel. Under the microscope: a relatively uniform morphology of large cells arranged diffusely can be seen. The cell morphology is diverse, resembling centroblasts, immunoblasts, and may also include multinucleated tumor cells with anaplastic features. Incidence Rate Diffuse large … Read more