Abstract: Antibody-drug conjugates (ADCs), known as “precision missiles” for cancer treatment, can accurately target tumor cells without harming normal tissues. The core of this technology lies inconjugation technology— the method of linking cytotoxic drugs (the warhead) with antibodies (the navigation system). This article starts from the working principle of ADCs, breaking down three major categories … Read more
01 Technical Overview 1.1 What is ADC? ADC, short for Antibody-Drug Conjugate, can be understood as a “biological missile” or “Trojan horse”. Antibody: is the “guidance system” or “shell of the Trojan horse”. It can accurately identify and bind to specific antigens (targets) on the surface of cancer cells. Drug: is the “warhead” or “soldiers … Read more
–01– Introduction For decades, advancements in antibody-drug conjugates (ADC) and bioconjugates have revolutionized targeted therapies for various diseases. Unlike traditional chemotherapy, ADCs selectively target tumor cells while sparing normal cells, making them highly suitable for cancer treatment. Currently, there are 17 types of ADCs approved by regulatory agencies in different countries worldwide. Over 200 more … Read more