During the progression of cancer, solid tumors often grow in areas lacking nutrients and oxygen. The abnormal structure of blood vessels and the high growth rate of tumors lead to cells that are far from blood vessels being in a state of hypoxia or low oxygen levels. The hypoxic environment within tumors reduces the efficacy … Read more
Sonodynamic Therapy (SDT) is a novel non-invasive tumor treatment method that utilizes ultrasound to activate sonosensitizers to generate reactive oxygen species (ROS) to induce tumor cell death. Based on the deep tissue penetration capability of ultrasound, SDT can treat deep tumors and has broad clinical transformation prospects. The main mechanism of SDT is the generation … Read more
iNature The photodynamic therapy (PDT) using oxygen-dependent type II photosensitizers is often limited by the hypoxic microenvironment of solid tumors. Type I photosensitizers generate oxygen-independent reactive oxygen species (ROS) under light irradiation, but they suffer from aggregation-caused quenching (ACQ) and low ROS generation efficiency. On December 19, 2024, the team led by Ge Zhishen from … Read more
iNature Sonochemotherapy (SCT) triggers an excessive production of reactive oxygen species (ROS) and controlled release of chemotherapeutic drugs through ultrasound, becoming a powerful cancer treatment method. However, achieving spatiotemporal controlled release of chemotherapeutic drugs during ROS generation remains a significant challenge. On December 17, 2024, a collaborative research paper titled“Cascade-Activatable Nanoprodrug System Augments Sonochemotherapy of … Read more
Cancer is a terrifying public health threat with low survival rates and a global prevalence. Therefore, exploring effective diagnostic and therapeutic methods is crucial. Traditional cancer treatments, including surgery, radiotherapy, and chemotherapy, often prove to be limited in efficacy and significant in side effects. Fortunately, fluorescence imaging-guided photodynamic therapy (FLI-guided PDT) offers a non-invasive strategy … Read more