reactive oxygen species

Controlled Electron Transfer: Development of Type I Photosensitizers through Energy Storage Pump Integration Strategy to Induce Long-term Tumor Immune Memory

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Controlled Electron Transfer: Development of Type I Photosensitizers through Energy Storage Pump Integration Strategy to Induce Long-term Tumor Immune Memory

1. Research Background In recent years, various tumor treatment methods, including surgery, chemotherapy, radiotherapy, and photodynamic therapy (PDT), have received widespread attention in the biomedical field. Among them, PDT kills cancer cells by generating reactive oxygen species (ROS) through the light activation of photosensitizers (PS), which is favored in clinical tumor treatment due to minimal … Read more

Controlled Electron Transfer: Implementing a Reservoir-Pump Integrated Strategy to Develop a Type I Photosensitizer for Evoking Long-Term Tumor Immunological Memory

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Controlled Electron Transfer: Implementing a Reservoir-Pump Integrated Strategy to Develop a Type I Photosensitizer for Evoking Long-Term Tumor Immunological Memory

Currently, the treatment of malignant tumors is a significant focus of public concern. In recent years, various tumor treatment methods, including surgical resection, chemotherapy, radiotherapy, and photodynamic therapy (PDT), have gained widespread attention in the biomedical field. Among these, PDT kills tumor cells by generating reactive oxygen species (ROS) through the light activation of photosensitizers … Read more

Oral Probiotic-Drug Conjugates for Targeted Colonization and On-Demand Drug Release in the Treatment of Ulcerative Colitis and Its Complications

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Oral Probiotic-Drug Conjugates for Targeted Colonization and On-Demand Drug Release in the Treatment of Ulcerative Colitis and Its Complications

Special Statement: Due to limited knowledge, there may be omissions and errors. Readers are encouraged to read critically and provide constructive feedback. Oral Probiotic-Drug Conjugates for Targeted Colonization and On-Demand Drug Release in the Treatment of Ulcerative Colitis and Its Complications Introduction This article constructs an orally administered, ROS-responsive probiotic-drug conjugate that achieves targeted colonization … Read more

J. Am. Chem. Soc: Flexible Double Bond Enhanced Photodynamic Therapy for Bacterial Resistance

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J. Am. Chem. Soc: Flexible Double Bond Enhanced Photodynamic Therapy for Bacterial Resistance

Abstract This study synthesized PS-S⁺, PS-D⁺, and PS-T⁺, which contain carbon-carbon (C-C), carbon-carbon double bond (C=C), and carbon-carbon triple bond (C≡C) linkers between the electron donor and acceptor parts, respectively. Unlike PS-S⁺ and PS-T⁺, PS-D⁺, which contains a flexible carbon-carbon double bond linker, can absorb energy under white light irradiation, enhancing the oscillation of the … Read more

Professor Dong Haifeng from Beijing University of Science and Technology in ACS NANO: Bimetallic Metal-Organic Framework Microneedle Array Promotes Wound Healing through Targeted Reactive Oxygen Species Generation and Disruption of Electron Transfer

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Professor Dong Haifeng from Beijing University of Science and Technology in ACS NANO: Bimetallic Metal-Organic Framework Microneedle Array Promotes Wound Healing through Targeted Reactive Oxygen Species Generation and Disruption of Electron Transfer

Click the blue text to follow us!Abstract Developing antibacterial strategies based on reactive oxygen species (ROS) overcomes the extremely short diffusion distance of ROS and disrupts bacterial electron transfer, opening a promising yet underexplored avenue for non-antibiotic therapies. In this study, the authors introduced a bimetallic metal-organic framework (MOF) with peroxidase-like (POD) activity, designed to … Read more

Hybrid Encryption Scheme Based on Elliptic Curves (ECIES)

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Hybrid Encryption Scheme Based on Elliptic Curves (ECIES)

0 Introduction With the help of ECC (Elliptic Curve Cryptography), we can utilize the powerful capabilities of public key encryption while achieving the speed and security of symmetric encryption. Therefore, we gradually turn to practical scenarios, focusing on the following categories: (1). Public Key Key Exchange Protocols: ECDH (P256), ECDH (P384), ECDH (P521), X25519 and … Read more

Algae-Based Antitumor Microbots

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Algae-Based Antitumor Microbots

During the progression of cancer, solid tumors often grow in areas lacking nutrients and oxygen. The abnormal structure of blood vessels and the high growth rate of tumors lead to cells that are far from blood vessels being in a state of hypoxia or low oxygen levels. The hypoxic environment within tumors reduces the efficacy … Read more

Cascaded Nano-Reactor Enhances Sonodynamic Therapy for Colon Cancer

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Cascaded Nano-Reactor Enhances Sonodynamic Therapy for Colon Cancer

Sonodynamic Therapy (SDT) is a novel non-invasive tumor treatment method that utilizes ultrasound to activate sonosensitizers to generate reactive oxygen species (ROS) to induce tumor cell death. Based on the deep tissue penetration capability of ultrasound, SDT can treat deep tumors and has broad clinical transformation prospects. The main mechanism of SDT is the generation … Read more

Potent Covalent Organic Framework Nanophotosensitizers for Photodynamic Immunotherapy

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Potent Covalent Organic Framework Nanophotosensitizers for Photodynamic Immunotherapy

iNature The photodynamic therapy (PDT) using oxygen-dependent type II photosensitizers is often limited by the hypoxic microenvironment of solid tumors. Type I photosensitizers generate oxygen-independent reactive oxygen species (ROS) under light irradiation, but they suffer from aggregation-caused quenching (ACQ) and low ROS generation efficiency. On December 19, 2024, the team led by Ge Zhishen from … Read more

Cascade-Activatable Nanoprodrug System Enhances Bladder Cancer Treatment

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Cascade-Activatable Nanoprodrug System Enhances Bladder Cancer Treatment

iNature Sonochemotherapy (SCT) triggers an excessive production of reactive oxygen species (ROS) and controlled release of chemotherapeutic drugs through ultrasound, becoming a powerful cancer treatment method. However, achieving spatiotemporal controlled release of chemotherapeutic drugs during ROS generation remains a significant challenge. On December 17, 2024, a collaborative research paper titled“Cascade-Activatable Nanoprodrug System Augments Sonochemotherapy of … Read more