Drug Release

Boosting Disassembly of π–π Stacked Supramolecular Nanodrugs under Tumor Microenvironment by Introducing Stimuli-Responsive Drug-Mates

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Boosting Disassembly of π–π Stacked Supramolecular Nanodrugs under Tumor Microenvironment by Introducing Stimuli-Responsive Drug-Mates

Click the blue text to follow us ～ Aggregate is dedicated to publishing fundamental and applied research in the field of aggregation science, covering significant advancements and innovative results in materials chemistry, physics, biology, and applied engineering. Aggregate has a broad scope for submissions, with research results related to single molecules or ionic layers being … Read more

Oral Probiotic-Drug Conjugates for Targeted Colonization and On-Demand Drug Release in the Treatment of Ulcerative Colitis and Its Complications

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Oral Probiotic-Drug Conjugates for Targeted Colonization and On-Demand Drug Release in the Treatment of Ulcerative Colitis and Its Complications

Special Statement: Due to limited knowledge, there may be omissions and errors. Readers are encouraged to read critically and provide constructive feedback. Oral Probiotic-Drug Conjugates for Targeted Colonization and On-Demand Drug Release in the Treatment of Ulcerative Colitis and Its Complications Introduction This article constructs an orally administered, ROS-responsive probiotic-drug conjugate that achieves targeted colonization … Read more

Probiotic–Drug Conjugates Achieve Synchronized Site-Specific Probiotic Colonization and On-Demand Drug Release against Ulcerative Colitis and Its Complications

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Probiotic–Drug Conjugates Achieve Synchronized Site-Specific Probiotic Colonization and On-Demand Drug Release against Ulcerative Colitis and Its Complications

Hello everyone, today I would like to share an article published in JACS titled “Probiotic–Drug Conjugates Achieve Synchronized Site-Specific Probiotic Colonization and On-Demand Drug Release against Ulcerative Colitis and Its Complications.” The corresponding authors are Professors Gao Huiyuan, Sun Jin, and Sun Mengchi from Shenyang Pharmaceutical University, who study active substances from traditional Chinese medicine, … Read more

JACS | New Direction for ADC: Triggerable Probiotic-Drug Conjugates

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JACS | New Direction for ADC: Triggerable Probiotic-Drug Conjugates

Ulcerative colitis (UC) is a chronic, recurrent inflammatory bowel disease that not only significantly reduces the quality of life for patients but also sharply increases the risk of colorectal cancer (CAC) due to prolonged inflammation. Currently, oral probiotics are considered a promising biological therapy for UC due to their advantages in regulating gut microbiota and … Read more

Professor Luo Binghong’s Team from Jinan University Publishes in ACS Nano: A Multifunctional 3D Printed Scaffold with Spatiotemporal Release of Multiple Drugs for Bone Regeneration

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Professor Luo Binghong's Team from Jinan University Publishes in ACS Nano: A Multifunctional 3D Printed Scaffold with Spatiotemporal Release of Multiple Drugs for Bone Regeneration

Bone defects are a common and challenging issue in the medical field. The development of biomaterials with excellent bone repair capabilities and economic practicality is of significant practical importance for the clinical treatment of bone defects. In recent years, tissue-engineered scaffolds have become increasingly popular in the treatment of bone defects. Notably, the process of … Read more

Professor Luo Binghong’s Team from Jinan University Publishes in ACS Nano: Multifunctional 3D Printed Scaffolds with Spatiotemporal Drug Release Functions for Bone Regeneration

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Professor Luo Binghong's Team from Jinan University Publishes in ACS Nano: Multifunctional 3D Printed Scaffolds with Spatiotemporal Drug Release Functions for Bone Regeneration

Bone defects are a common and challenging issue in the medical field. The development of biomaterials with excellent bone repair capabilities and cost-effectiveness is of significant practical importance for the clinical treatment of bone defects. In recent years, tissue-engineered scaffolds have become increasingly popular for the treatment of bone defects. Notably, the process of bone … Read more

In-Depth Analysis of Antibody-Drug Conjugates (ADC) – Part 3

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In-Depth Analysis of Antibody-Drug Conjugates (ADC) - Part 3

Introduction Antibody-drug conjugates (ADCs) are “biological bullets” formed by conjugating cytotoxic drugs (payloads) to antibodies via a “linker.” They consist of five components: target, antibody, linker, payload, and conjugation method. Each part is crucial to the function of ADCs, but today we will focus on the linker that connects the antibody and payload, examining the … Read more