Professor Li Xingshu and Academician Juyoung Yoon in Angew: Hypoxia-triggered Bioreduction of Hydrophilic Type I Photosensitizers for Switchable In Vivo Photoacoustic Imaging and High-specificity Cancer Phototherapy

Professor Li Xingshu and Academician Juyoung Yoon in Angew: Hypoxia-triggered Bioreduction of Hydrophilic Type I Photosensitizers for Switchable In Vivo Photoacoustic Imaging and High-specificity Cancer Phototherapy

Click the blue text Follow us Background Introduction Hypoxia has been identified as a prominent feature within tumors, resulting from the rapid and aggressive growth of tumor cells and abnormal vascularization. Consequently, the low concentration of oxygen (O2) in the hypoxic tumor microenvironment significantly weakens O2-dependent physiological mechanisms and further reduces therapeutic efficacy, such as … Read more

Potent Covalent Organic Framework Nanophotosensitizers for Photodynamic Immunotherapy

Potent Covalent Organic Framework Nanophotosensitizers for Photodynamic Immunotherapy

iNature The photodynamic therapy (PDT) using oxygen-dependent type II photosensitizers is often limited by the hypoxic microenvironment of solid tumors. Type I photosensitizers generate oxygen-independent reactive oxygen species (ROS) under light irradiation, but they suffer from aggregation-caused quenching (ACQ) and low ROS generation efficiency. On December 19, 2024, the team led by Ge Zhishen from … Read more