How Activated PKA is Reset

How Activated PKA is Reset

Hello everyone, today I am sharing an article published in JACS titled “Multiplicity of Regulatory Subunit Conformations Defines Structural Ensemble of Reset Protein Kinase A Holoenzyme.” The corresponding author is Professor Ganesh S. Anand from Pennsylvania State University, whose research focuses on using mass spectrometry tools to reveal the dynamic processes of cellular macromolecular assembly. … Read more

Cascade-Activatable Nanoprodrug System Enhances Bladder Cancer Treatment

Cascade-Activatable Nanoprodrug System Enhances Bladder Cancer Treatment

iNature Sonochemotherapy (SCT) triggers an excessive production of reactive oxygen species (ROS) and controlled release of chemotherapeutic drugs through ultrasound, becoming a powerful cancer treatment method. However, achieving spatiotemporal controlled release of chemotherapeutic drugs during ROS generation remains a significant challenge. On December 17, 2024, a collaborative research paper titled“Cascade-Activatable Nanoprodrug System Augments Sonochemotherapy of … Read more