microglial pyroptosis

Controlled Electron Transfer: Implementing a Reservoir-Pump Integrated Strategy to Develop a Type I Photosensitizer for Evoking Long-Term Tumor Immunological Memory

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Controlled Electron Transfer: Implementing a Reservoir-Pump Integrated Strategy to Develop a Type I Photosensitizer for Evoking Long-Term Tumor Immunological Memory

Currently, the treatment of malignant tumors is a significant focus of public concern. In recent years, various tumor treatment methods, including surgical resection, chemotherapy, radiotherapy, and photodynamic therapy (PDT), have gained widespread attention in the biomedical field. Among these, PDT kills tumor cells by generating reactive oxygen species (ROS) through the light activation of photosensitizers … Read more

Southern Medical University Study: Vitamin C Combined with Immunotherapy Breaks Through Lung Cancer Drug Resistance

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Southern Medical University Study: Vitamin C Combined with Immunotherapy Breaks Through Lung Cancer Drug Resistance

01 In the treatment of non-small cell lung cancer (NSCLC), a subtype characterized by the deletion of the LKB1 gene has long left clinicians at a loss. These tumors are referred to as “immune deserts”—with almost no trace of anti-cancer T cells, they exhibit near-complete resistance to PD-1/PD-L1 immune checkpoint inhibitors (ICIs), resulting in poor … Read more

Blocking the C/EBPβ-Fcgr1 Regulatory Axis Inhibits Microglial Pyroptosis and Improves Neurological Recovery

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Blocking the C/EBPβ-Fcgr1 Regulatory Axis Inhibits Microglial Pyroptosis and Improves Neurological Recovery

PMID: 39891259 DOI: 10.1186/s12974-024-03171-yIF: 11.7 Q1 Abstract CAAT/Enhancer Binding Protein β (C/EBPβ) is associated with the inflammatory response in neurodegenerative diseases, particularly in the brain. However, the regulatory role of C/EBPβ in spinal cord injury (SCI) and its impact on neurological recovery remain unknown. In this study, the research team observed a significant upregulation of … Read more