Antibody-drug Conjugates

Comprehensive Overview of Antibody-Drug Conjugates (ADCs)

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Comprehensive Overview of Antibody-Drug Conjugates (ADCs)

Antibody-drug conjugates (ADCs) are formed by linking monoclonal antibodies targeting specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effects of traditional small molecule chemotherapy with the tumor-targeting properties of antibody drugs. ADCs consist of three main components: the antibody responsible for selectively recognizing cancer cell surface antigens, the drug payload … Read more

Comprehensive Overview of Antibody-Drug Conjugates (ADCs)

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Comprehensive Overview of Antibody-Drug Conjugates (ADCs)

Introduction Antibody-drug conjugates (ADC) combine the high specificity of monoclonal antibodies with the high potency of small molecule cytotoxic drugs to enhance the targeting of cancer therapies and reduce side effects. Compared to traditional antibodies or antibody fragments, ADCs can release highly active cytotoxins within tumor tissues, theoretically leading to higher efficacy. ADCs have undergone … Read more

Mechanisms of ADC Toxicity and Strategies to Enhance Tolerability

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Mechanisms of ADC Toxicity and Strategies to Enhance Tolerability

Key Content Preview:In recent years, antibody-drug conjugates (ADCs) have developed rapidly. As of August 2023, there are a total of 15 ADCs on the market globally, with over 1200 drugs under research. In June this year, Nature Biotechnology published a brief report titled “ADCs’ Revival”, highlighting the “breakthrough momentum” of ADCs in new drug development. … Read more

A Detailed Explanation of ADC Drugs: Innovative Therapies for Lung Cancer

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A Detailed Explanation of ADC Drugs: Innovative Therapies for Lung Cancer

Antibody-drug conjugates (ADC), also known as “magic bullets,” use monoclonal antibodies (Antibody) to deliver small molecule drugs (Drug) directly to tumor cells expressing specific antigens through a linker (Conjugate). In recent years, ADC drugs have rewritten the treatment guidelines for blood cancers, breast cancer, ovarian cancer, and lung cancer, providing patients with significantly improved clinical … Read more

Mechanisms of ADC Resistance and Countermeasures

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Mechanisms of ADC Resistance and Countermeasures

ADC (Antibody-drug conjugate) is a new type of drug for cancer treatment. It is a complex formed by combining anti-tumor drugs with antibodies, allowing for precise delivery of the drug into tumor cells, thereby achieving targeted treatment of tumor cells. However, with the widespread application of ADCs, research has found that the issue of ADC … Read more

Fundamentals of Clinical Pharmacology of ADCs

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Fundamentals of Clinical Pharmacology of ADCs

Introduction Antibody-drug conjugates (ADC) are formed by linking monoclonal antibodies targeting specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs. Since the first ADC, Gemtuzumab-ozogamicin (brand name: Mylotarg), was approved for the treatment of CD33-positive acute myeloid … Read more

An In-Depth Analysis of ADC Drug Resistance Mechanisms

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An In-Depth Analysis of ADC Drug Resistance Mechanisms

Antibody-drug conjugates (ADC) are formed by the coupling of specific targeting monoclonal antibodies and highly active cytotoxic drugs through linkers. With their unique pharmaceutical properties, ADC drugs exhibit strong anti-tumor activity in the field of cancer therapy, while also offering higher safety compared to traditional chemotherapy. In recent years, the development of ADC drugs in … Read more

Mechanisms of Non-Targeted Uptake and Toxicity of ADC Drugs

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Mechanisms of Non-Targeted Uptake and Toxicity of ADC Drugs

1 Introduction Antibody-drug conjugates (ADCs) are a new type of highly effective biopharmaceuticals that link antibodies with biologically active small molecule cytotoxic payloads through linkers. ADCs are designed to improve the therapeutic index (TI) of chemotherapeutic agents by selectively delivering cytotoxic drugs to tumor cells while reducing exposure in normal cells. Despite using a large … Read more

The Development Momentum of ADC Drugs

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The Development Momentum of ADC Drugs

Source: YaoDu Written by: -7℃ Edited by: Wanzi ADC (Antibody Drug Conjugate) is a complex formed by linking cytotoxic drugs to monoclonal antibodies targeting tumors, which combines the characteristics of targeted drugs and chemotherapy drugs, enabling precise treatment. The concept of ADC drugs was proposed as early as 1900, but it remained theoretical for a … Read more

Understanding ADC Drugs: A Visual Guide

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Understanding ADC Drugs: A Visual Guide

After the era of chemotherapy, targeted therapy, and immunotherapy, the ADC (antibody-drug conjugate) drugs, which couple cytotoxic drugs with targeted monoclonal antibodies, have opened the era of the fourth ladder of tumor drug therapy with excellent results. They have now become a new class of drugs in tumor treatment that cannot be ignored both domestically … Read more