Antibody-drug Conjugates

Exploring the Stories Behind ADC Payloads: Traditional Chemotherapeutics

by
Exploring the Stories Behind ADC Payloads: Traditional Chemotherapeutics

Although the concept of antibody-drug conjugates (ADCs) seems straightforward, developing successful and effective drugs involves numerous challenges. For a successful ADC product, scientists must optimize various parameters, including ADC stability (for instance, the drug payload should not be released before the ADC reaches its target in the body), pharmacokinetics (e.g., the payload should not accumulate … Read more

ADC Technology Report: Predicting The Future Of Next-Generation ADCs

by
ADC Technology Report: Predicting The Future Of Next-Generation ADCs

Source: Beike Society Antibody-drug conjugates (ADCs) have become a popular avenue in tumor treatment in recent years, typically covalently linking a monoclonal antibody (mAb) to a cytotoxic drug (payload) via a chemically synthesized linker. ADCs combine the advantages of highly specific targeting capabilities with potent killing effects, achieving precise and efficient elimination of cancer cells. … Read more

FDA Experts Analyze Challenges and Prospects of ADC Drugs

by
FDA Experts Analyze Challenges and Prospects of ADC Drugs

△ A grand contribution, 1 main forum, 5 sub-forums, 9 thematic forums, hundreds of industry leaders, many renowned clinical PIs and dozens of CMOs gathered, a thousand-person conference awaits you! ▼ Antibody-drug conjugates (ADCs) are currently developing rapidly, utilizing antibodies to selectively deliver cytotoxic drugs to tumor sites. As of May 2021, the U.S. Food … Read more

ADC Technology Report: Forecast of Next-Generation ADC Development

by
ADC Technology Report: Forecast of Next-Generation ADC Development

Antibody-drug conjugates (ADCs) have become a popular avenue in tumor treatment in recent years, typically covalently linking monoclonal antibodies (mAbs) with cytotoxic drugs (payloads) via chemically synthesized linkers. ADCs combine the advantages of highly specific targeting capabilities and effective killing actions, achieving precise and efficient clearance of cancer cells.Figure 1. Structure and characteristics of ADC … Read more

Four Classic Site-Specific Coupling Technologies for ADCs

by

ADCs have become a promising class of anti-tumor drugs, with over a dozen ADCs approved for treating various types of cancer patients. Traditional ADCs utilize the amino groups of antibody lysines or the thiol groups obtained from the reduction of inter-chain disulfide bonds in cysteines for coupling. However, their uniformity is poor, and stability is … Read more

Development of Analytical Methods for ADC Drugs

by
Development of Analytical Methods for ADC Drugs

Antibody-drug conjugates (ADC) mainly consist of three “modules”: an antibody (generally a monoclonal antibody), a linker, and a cytotoxic drug (Payload). In recent years, ADC drugs have stood out among biopharmaceuticals due to their combination of the potent killing effect of chemotherapy drugs and the precise targeting of antibody drugs, earning them the title of … Read more

Overview of Non-Targeted Uptake and Toxicity Mechanisms of ADC Drugs

by
Overview of Non-Targeted Uptake and Toxicity Mechanisms of ADC Drugs

Source: YaoDu Author: Cheng Chuan Yuan Hang Editor: Wan Zi 1 Introduction Antibody-Drug Conjugates (ADCs) are a novel class of highly effective biopharmaceuticals that link antibodies (Antibody) to biologically active small-molecule cytotoxic payloads (Payload) via linkers (Linker). ADCs aim to enhance the therapeutic index (TI) of chemotherapeutic agents by more selectively delivering cytotoxic drugs to … Read more

Comprehensive Analysis of ADC Drug Screening

by
Comprehensive Analysis of ADC Drug Screening

1. Overview Antibody-drug conjugates (ADCs) rejuvenate the concept of targeted chemotherapy by coupling cytotoxic payloads to antibodies. The first stage of the complex intracellular toxin delivery process of ADCs is endocytosis. Analyzing the endocytic action of target receptors and ADCs can greatly advance preclinical research, clinical translation, and patient treatment outcomes. The in vitro efficacy … Read more

Structure and Function of Antibody-Drug Conjugates (ADC)

by

Previous Reviews 2023 Overview of Antibody Drug Industry Development History of Monoclonal Antibodies, This Article is Enough! Brief Discussion on the Mechanism of Action and Advantages/Disadvantages of Antibodies How to Name Monoclonal Antibodies, Read This! Magic Bullet – ADC Antibody-drug conjugates (ADC) are a class of targeted biological agents composed of an antibody, a linker, … Read more

Fundamentals of Clinical Pharmacology of ADCs

by

Introduction Antibody-drug conjugates (ADC) are formed by linking monoclonal antibodies that target specific antigens to small-molecule cytotoxic drugs through linkers, combining the powerful killing effects of traditional small-molecule chemotherapy with the tumor-targeting properties of antibody drugs. Since the first ADC (Gemtuzumab-ozogamicin (brand name: Mylotarg)) was approved for the treatment of CD33-positive acute myeloid leukemia, dozens … Read more