After ADC, the ‘Bottlebrush’ ABC Has Arrived!

After ADC, the 'Bottlebrush' ABC Has Arrived!

“Structure similar to a bottlebrush” In recent years, antibody-drug conjugates (ADCs) have emerged as a novel targeted therapy strategy, achieving precise targeting of cancer cells by covalently linking monoclonal antibodies with small molecule drugs. They have demonstrated good efficacy and safety in the treatment of various cancers. However, traditional ADCs still face many limitations in … Read more

Antibody-Bottlebrush Prodrug Conjugates for Targeted Cancer Therapy

Antibody-Bottlebrush Prodrug Conjugates for Targeted Cancer Therapy

Recently, Professor Jeremiah A. Johnson from the Massachusetts Institute of Technology and his research team proposed a targeted cancer therapy using antibody–bottlebrush prodrug conjugates(Antibody-Bottlebrush Prodrug Conjugates, ABC). This research was published in the international academic journal Nature Biotechnology on September 9, 2025. A summary of this article and expert/editorial opinions were also published in the … Read more