Forensic Toxicology

Organ-on-a-Chip and Organoids: Revolutionary Technologies in Alternative Toxicology

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Organ-on-a-Chip and Organoids: Revolutionary Technologies in Alternative Toxicology

1. Development Background and Technical Needs in Alternative Toxicology 1.1 Limitations of Traditional Toxicology Methods Traditional toxicology relies on animal testing and two-dimensional cell cultures, which have significant drawbacks: animal testing fails to accurately predict about 60% of hepatotoxic drugs due to interspecies differences (e.g., mouse vs. human liver metabolism), as seen in the troglitazone … Read more

Essential Guide: Non-Clinical Pharmacology and Toxicology Assessment of ADCs

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Essential Guide: Non-Clinical Pharmacology and Toxicology Assessment of ADCs

Recently, the ADC (Antibody-Drug Conjugate) conference has been held one after another, with major biotech companies competing to report their ADC pipelines. It is expected that 2024 will still be the main stage for ADCs. Developing an entry-level ADC seems not too difficult, but how to evaluate the pharmacology and toxicology in the preclinical stage … Read more

Non-Clinical Research of ADC Drugs

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Non-Clinical Research of ADC Drugs

Click the above Xingzhou Drug ▲ Follow This year, CED released the draft for comments on the “Technical Guidelines for Non-Clinical Research of Antibody-Drug Conjugates (ADC)”, which provides assistance for companies conducting non-clinical research on ADCs.It provides guidance on non-clinical studies such as “pharmacology, safety pharmacology, pharmacokinetics, and toxicology”. (1) PharmacologyIn the early development of … Read more

Non-Clinical Research Guidelines for Antibody-Drug Conjugates (ADCs)

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Non-Clinical Research Guidelines for Antibody-Drug Conjugates (ADCs)

This year, CED released the draft for “Technical Guidelines for Non-Clinical Research of Antibody-Drug Conjugates” to assist companies in conducting non-clinical research on ADCs.It provides guidance on non-clinical studies such as “pharmacology, safety pharmacology, pharmacokinetics, and toxicology.”(1) PharmacologyIn the early development of ADCs, studies on the in vitro and in vivo pharmacological/efficacy effects of ADCs … Read more

Recent Advances in Antibody-Drug Conjugates (ADCs) Development and Considerations for Non-Clinical Review

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Recent Advances in Antibody-Drug Conjugates (ADCs) Development and Considerations for Non-Clinical Review

Introduction As one of the most active innovative drug development areas at present, Antibody-Drug Conjugates (ADCs) are rising at an astonishing pace. The global industry interest continues to heat up, with ADC innovative drugs being approved one after another. As of March 2025, a total of 17 ADC products have been approved for market release … Read more

A Comprehensive Guide to Non-Clinical Pharmacology and Toxicology Assessment of ADCs

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A Comprehensive Guide to Non-Clinical Pharmacology and Toxicology Assessment of ADCs

Recently, ADC (Antibody-Drug Conjugate) conferences have been held one after another, with major biotech companies competing to report their ADC pipelines. It is expected that 2024 will still be the main venue for ADCs. Developing an entry-level ADC seems not difficult, but evaluating the pharmacology and toxicology in the preclinical stage has become a top … Read more

Application and Prospects of Artificial Intelligence in Forensic Toxicology

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Application and Prospects of Artificial Intelligence in Forensic Toxicology

National Certification Remote Forensic Base With You . . Learning and Practicing AbstractWith the rapid development of artificial intelligence (AI), the intersection of forensic toxicology and AI has increasingly become a research hotspot in forensic science, providing new ideas and methods to solve traditional forensic toxicology issues. This article reviews recent domestic and international research, … Read more