Drug Screening

Gene-Encoded Biosensor STATeLights: A Breakthrough Tool for Real-Time Visualization of STAT Activation in Live Cells

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Gene-Encoded Biosensor STATeLights: A Breakthrough Tool for Real-Time Visualization of STAT Activation in Live Cells

In the field of cell signaling research, the signal transducer and activator of transcription (STAT) family plays a critical role, with abnormal activation closely related to various diseases such as cancer and autoimmune diseases, making it an important drug target. However, the long-standing lack of effective tools for real-time monitoring of STAT activation has hindered … Read more

Innovative Delivery: Comprehensive Analysis of ‘Magic Bullet’ ADC Drug Screening

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Innovative Delivery: Comprehensive Analysis of 'Magic Bullet' ADC Drug Screening

Authors: Li Jiaxing, Hu Linghong, Hu YuhaoImages: Yang Zhenzhen1. Summary Antibody-drug conjugates (ADCs) rejuvenate the concept of targeted chemotherapy by coupling cytotoxic payloads to antibodies. The first stage of the complex intracellular toxin delivery process of ADCs is endocytosis. Analyzing the endocytosis of target receptors and ADCs can greatly enhance preclinical studies, clinical translation, and … Read more

Laboratory on a Chip: Microfluidic Chips

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Laboratory on a Chip: Microfluidic Chips

Everyone ยท Technology FrontierMASTERS Ding Xianting Distinguished Professor at the School of Biomedical Engineering, Shanghai Jiao Tong University, and Deputy Director of the International Cooperation and Exchange Office It is well known that during the clinical trial process before drugs are marketed, traditional methods mainly rely on animal models to complete a large number of … Read more