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Principles and Clinical Applications of Diffusion Weighted Imaging (DWI and ADC)

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Principles and Clinical Applications of Diffusion Weighted Imaging (DWI and ADC)

What is Functional Magnetic Resonance Imaging? Various magnetic resonance imaging techniques based primarily on conventional T1WI and T2WI mainly display the morphological structures of human organs or tissues and their signal intensity changes, collectively referred to as conventional MRI examinations or conventional MR imaging sequences. With the development of MRI system hardware and software, various … Read more

Understanding ADCs and Their Future

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Understanding ADCs and Their Future

Since the end of 2019 and the beginning of 2020, I have been looking at ADCs, and I have discussed with many experts in the field, leading to many misunderstandings, and my understanding has been continuously refreshed. Many articles about ADCs exist, but many of them contain misunderstandings. Now, there are more successful and failed … Read more

ADC Technology Report: Prospects for Next-Generation ADC Development

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ADC Technology Report: Prospects for Next-Generation ADC Development

Antibody-drug conjugates (ADCs) have become a popular avenue for cancer treatment in recent years. They typically consist of monoclonal antibodies (mAbs) covalently linked to cytotoxic drugs (payloads) through chemically synthesized linkers. ADCs combine the advantages of high specificity targeting and effective killing action, achieving precise and efficient elimination of cancer cells. Figure 1. Structure and … Read more

Introduction to Antibody-Drug Conjugates (ADC)

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Introduction to Antibody-Drug Conjugates (ADC)

Since the first use of cytotoxic chemicals to treat cancer, oncologists have been searching for ways to improve efficacy without significantly increasing overall toxicity to patients. One of the methods attempted to enhance the killing effect on tumor cells is the use of cytotoxic agents with potency at picomolar or lower levels (such as microtubule … Read more

Design Mechanisms and Adverse Reaction Management of Antibody-Drug Conjugates (ADCs)

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Design Mechanisms and Adverse Reaction Management of Antibody-Drug Conjugates (ADCs)

Introduction: Antibody-drug conjugates (ADC) consist of antibodies, linkers, and small molecule cytotoxic drugs, combining high specificity and high cytotoxicity advantages. However, their structural diversity and complexity, along with the low content of released small molecule toxins in the circulatory system, pose significant challenges for pharmacokinetic studies. This article will discuss the mechanisms, design, safety features, … Read more

Comprehensive Analysis of Antibody-Drug Conjugate (ADC) Technology

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Comprehensive Analysis of Antibody-Drug Conjugate (ADC) Technology

Antibody-drug conjugates (ADC) are a class of targeted cancer therapies that combine the high specificity of monoclonal antibodies with the potent activity of small molecule cytotoxic drugs to enhance tumor targeting and reduce side effects. Compared to traditional antibodies or antibody fragments, ADCs theoretically have higher efficacy due to their ability to release highly active … Read more

Understanding ADC Drugs: A Visual Guide

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Understanding ADC Drugs: A Visual Guide

ADC In the era following chemotherapy, targeted therapy, and immunotherapy, ADC drugs, which combine cytotoxic drugs with targeted monoclonal antibodies, have opened a new era of fourth-line cancer treatment with exceptional results. They have become a significant class of new drugs in cancer treatment both domestically and internationally. So, what are ADC drugs (antibody-drug conjugates)? … Read more

Overview of ADC Drug Development Landscape

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Overview of ADC Drug Development Landscape

Antibody-drug conjugates (ADC) are also known as “biological missiles”. They connect cytotoxic drugs similar to chemotherapy with monoclonal antibodies, consisting of three parts: antibodies, linkers, and payloads (small molecule cytotoxic drugs). This combination achieves the dual advantages of small molecules and antibody drugs, enabling targeted killing of tumors and other diseases. In recent years, global … Read more

Next Generation Antibody-Drug Conjugates (ADCs): What They Look Like

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Next Generation Antibody-Drug Conjugates (ADCs): What They Look Like

Antibody-drug conjugates (ADCs) have become an important treatment method in the field of oncology, offering superior clinical characteristics compared to chemotherapy. However, the application of ADCs still faces two significant challenges. First, there are very few validated payloads with proven mechanisms of action (MoA), which limits the expansion of indications. Approved ADC payloads cover three … Read more

Combination Therapy of Antibody-Drug Conjugates (ADCs)

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Combination Therapy of Antibody-Drug Conjugates (ADCs)

Introduction Antibody-drug conjugates (ADCs) are formed by linking monoclonal antibodies that target specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs.ADCs consist of three main components: the antibody responsible for selectively recognizing cancer cell surface antigens, the … Read more