The Concept and Development History of ADC The treatment of tumors has always undergone a continuous transformation from theory to application, breaking and transforming again. As early as a century ago, scholars proposed the concept of antibody-drug conjugates (ADCs), vividly calling them “magic bullets,” aimed at targeting specific antigens that may exist on the surface … Read more
Please click the “Bio New Thinking” above to follow more exciting content! Written by / Jia Bei Pharmaceutical @ Bai Ao Yun Testing Reviewed by / Gu Du Pharmacist @ Bio New Thinking Antibody-drug conjugates (ADCs) are large molecule drugs formed by conjugating monoclonal antibodies with highly potent small molecule drugs via linkers, enabling targeted … Read more
Breast cancer, regarded as the “killer of beauty,” is a malignant tumor that severely threatens women’s health, with an increasing incidence year by year. Antibody-drug conjugates (ADC), as a new type of therapeutic drug, have become a hot research topic in the field of breast cancer due to their advantages of “high efficacy and low … Read more
Introduction Antibody-drug conjugates (ADCs) are “biological bullets” formed by conjugating cytotoxic drugs (payloads) to antibodies via a “linker.” They consist of five components: target, antibody, linker, payload, and conjugation method. Each part is crucial to the function of ADCs, but today we will focus on the linker that connects the antibody and payload, examining the … Read more
Since the first use of cytotoxic chemicals to treat cancer, oncologists have been searching for ways to enhance efficacy without significantly increasing overall toxicity to patients. One of the methods attempted to improve the killing effect on tumor cells is the use of cytotoxic agents with potency at picomolar or lower levels (such as microtubule … Read more
History of ADC Drug Development Phase 1 (1906-1982), the concept of targeted therapy was proposed, and the technology took shape. Phase 2 (1983-2011), transition from clinical trials to commercialization, Mylotarg® was approved for market. Phase 3 (2012-present), explosive growth of ADC products. The five key elements of ADC drugs are target, antibody, linker, cytotoxic agent, … Read more
The potential difference generated by the Hall effect is very small, often only a few microvolts. Therefore, Hall sensors often have a built-in high-gain operational amplifier and may be combined with other system circuits based on overall requirements. The overall architecture is shown below. Typically, the final output signals from Hall sensors can be either … Read more
Abstract: In response to the current issues of low sampling rates and poor portability in signal acquisition systems, a design for a high-speed portable signal acquisition system based on FPGA is proposed. This design uses an FPGA chip to control an analog-to-digital converter (ADC) chip for high-speed signal sampling, then stores the data in a … Read more
Special Edition of ISSCC 2022, Session 10 On the morning of June 10, the 24th session of Doctoral Innovation in “Chip” was held online, featuring the 10th session of the 【ISSCC 2022 Special Edition】.Dr. Zhan Mingtao from Tsinghua University was invited to give a presentation titled “Low-Power High-Speed ADC Design“. The report was simultaneously broadcasted … Read more
Introduction to Common Microcontroller Chips STC Microcontroller The microcontrollers from STC are primarily based on the 8051 core, representing a new generation of enhanced microcontrollers. The instruction set is fully compatible with traditional 8051, offering speeds 8 to 12 times faster, equipped with ADC, 4-channel PWM, dual serial ports, a unique global ID, good encryption, and strong … Read more