In-Depth Analysis of ADC Technology Platforms

Representative ADC Technology Platforms As a combination drug, any component of an ADC can be replaced or modified.Therefore, the ADC combination technology platform has significant extensibility, allowing for the iterative combination of a rich variety of products.The development history of internationally leading ADC companies is rooted in having a competitive platform.Table 1 lists several representative … Read more

What Exactly Is an ADC?

What Exactly Is an ADC?

Known as magic bullets, ADCs have been highly praised in recent years. The design concept of these drugs is clear: to utilize the high specificity of antigen-antibody binding to selectively deliver toxins to antigen-positive cells, thereby selectively killing target cells and reducing damage to normal cells. However, like other drugs, the actual performance of ADCs … Read more

Understanding ADCs: A Comprehensive Guide

Understanding ADCs: A Comprehensive Guide

Introduction Antibody-Drug Conjugates (ADCs) are targeted therapies that consist of antibodies, linkers, and cytotoxic drugs, using monoclonal antibodies as carriers to efficiently deliver cytotoxic drugs to target tumor cells in a targeted manner, combining the powerful killing effect of traditional chemotherapy with the tumor-targeting capability of antibody drugs. An ideal ADC maintains stability in the … Read more

Selection of Target Antigens in ADC Design

Selection of Target Antigens in ADC Design

Source: Xiaoyao Shuo Yao Introduction Antibody-drug conjugates (ADC) are a powerful cancer treatment method that combines monoclonal antibodies targeting specific antigens with small molecule cytotoxic drugs linked by a linker. ADCs utilize the specificity of antibodies for their target antigens, combined with the potency of cytotoxic drugs, to selectively kill tumor cells expressing the target … Read more

Review of ADC Drugs: Current Status and Future Directions

Review of ADC Drugs: Current Status and Future Directions

Antibody-Drug Conjugates (ADCs) are one of the fastest-developing treatments in the field of oncology, with 15 ADCs already approved and over 210 currently undergoing clinical trials. In recent years, the development of ADC drugs has entered a flourishing phase, especially demonstrating significant efficacy and good safety profiles against targets such as HER2, EGFR, Trop2, CLDN18.2, … Read more

Fundamentals of Clinical Pharmacology of ADCs

Antibody-drug conjugates (ADC) are formed by linking monoclonal antibodies that target specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs. Since the first ADC (Gemtuzumab-ozogamicin, trade name: Mylotarg) was approved for the treatment of CD33-positive acute myeloid … Read more

Research on ADC Combination Therapy

Research on ADC Combination Therapy

Introduction Antibody-drug conjugates(ADC) are formed by linking monoclonal antibodies targeting specific antigens with small molecule cytotoxic drugs through linkers, combining the powerful killing effect of traditional small molecule chemotherapy with the tumor targeting ability of antibody drugs. ADC consists of three main components: the antibody responsible for selectively recognizing cancer cell surface antigens, the drug … Read more

Comprehensive Overview of ADC Drug Development

Comprehensive Overview of ADC Drug Development

What Is ADC? Antibody-drug conjugates (ADC) are a new type of targeted therapeutic drug, composed of monoclonal antibodies that specifically target antigens linked to small molecule cytotoxic drugs via linkers. They combine the powerful killing effect of traditional small molecule chemotherapy with the tumor-targeting capability of antibody drugs. This structure allowsADC to deliver drugs directly … Read more

Digital Transmission of Analog Signals via Long-Distance I2C Bus

Digital Transmission of Analog Signals via Long-Distance I2C Bus

Click the above “Easily Learn Electronics” to follow us and easily learn electronic knowledge. Easily Learn Electronics Subscription Daily updates on technical articles in the electronics industry and the latest information on microcontrollers, making it easy to learn anytime, anywhere. The Inter-Integrated Circuit (I2C) bus is a synchronous serial data communication bus, where communication is … Read more

Analysis of Network Audio Protocols and Their Application in 4K Broadcast Audio Systems

Analysis of Network Audio Protocols and Their Application in 4K Broadcast Audio Systems

Digital network audio has gradually integrated into daily work, bringing great convenience to data transmission, signal scheduling, content distribution, and other related applications. In the early development of network audio, the incompatibility of various protocols and the inability of different brand devices to communicate directly limited its application. With the advancement of technology, network audio … Read more