Oscilloscopes Are Simple Yet Complex! But Why Are Oscilloscopes So Expensive? Most cost thousands or tens of thousands, why are they so expensive? Structure of Digital Oscilloscopes The Reason Oscilloscopes Are Considered Simple Is That An Oscilloscope Is A Test Instrument That Can Display The Dynamic Waveform Of Voltage Signals. An Oscilloscope Converts Time-Varying Voltage … Read more
Written by/ Shi Bin, Tang Mingze Under the impact of television, broadcasting has gained a “revival” due to the popularity of cars, thus broadcasting is also referred to as “media on wheels.” Entering the digital network era, especially with the continuous maturity of 5G network communication technology and Internet of Things technology, the “Internet of … Read more
Antibody drug conjugates (antibody drug conjugate, ADC) are a class of emerging targeted anti-cancer drugs that have shown excellent efficacy in clinical trials against various refractory and metastatic solid tumors. However, the therapeutic effects and potential biological mechanisms of ADC drugs used in combination with other targeted therapies remain unexplored. Recently, Researcher Guo Peng from … Read more
1. Basic Principles and Classification of D/A Converters T-type Resistor Network D/A Converter: 2. Correspondence between Output Voltage and Digital Quantity 3. Main Performance Indicators of D/A Converters 1. Resolution Resolution refers to the change in the corresponding output analog quantity (voltage or current) when the least significant bit (LSB) of the input digital quantity … Read more
Protein Hydrolysis Targeted Chimeras (PROTAC) are bringing revolutionary changes to the fields of biology and medicinal chemistry. PROTAC consists of a target protein ligand, an E3 ligase ligand, and a spacer group[Unlike the linker used in antibody-drug conjugates, here we specifically use “spacer” instead of the commonly seen “linker” in PROTAC literature]. PROTAC structural composition … Read more
To deliver chemotherapy drugs more effectively, small molecule drug conjugates (SMDC), antibody-drug conjugates (ADC), and degrader-antibody conjugates (DAC) have been explored and developed, providing selective delivery while improving the therapeutic index. What are their similarities and differences? What are their respective advantages? What is the current state of research? What does the future hold? This … Read more
In electronic design, the layout and routing of Analog-to-Digital Converters (ADC) and Digital-to-Analog Converters (DAC) are key factors affecting system performance. Proper routing can not only improve signal quality and reduce noise interference but also optimize the overall performance of the system. 1. Pre-define Routing Areas 2. Separate Analog and Digital Signals 3. Optimize the … Read more
Introduction Degrader-Antibody Conjugates (DAC) are a novel entity that combines the payload of Protein Degradation Targeting Chimeras (PROTAC) with monoclonal antibodies through a type of chemical linker (DAC =PROTAC + ADC). This article collects several examples of DAC from scientific and patent literature and documents specific challenges associated with DAC construction. Overall, these examples indicate … Read more
DAC (Digital-to-Analog Converter) and ADC (Analog-to-Digital Converter) are essential components for converting between digital and analog signals, widely used in electronic systems for various applications such as digital signal processing, data acquisition, and control. So, do you know how to implement DAC and ADC? Methods for Implementing DAC 1. Resistor Network A resistor network is … Read more
Currently, there are 15 ADC drugs approved globally, among which 6 ADC drugs have been approved in China, namely Trastuzumab emtansine, Brentuximab vedotin, Trastuzumab deruxtecan, Vidofludimus, Gemtuzumab ozogamicin, and Sacituzumab govitecan. This article provides a brief summary based on the currently approved ADC drugs worldwide, the types of tumors they are suitable for, and how … Read more