Cationic Nanoparticles

In Situ Electron Microscopy Study of Dynamic Structural Changes in CuZn Bimetallic Nanoparticles

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In Situ Electron Microscopy Study of Dynamic Structural Changes in CuZn Bimetallic Nanoparticles

Background Introduction Bimetallic nanocomposites have gained widespread attention due to their tunable physicochemical properties and significant applications in engineering and catalysis. In nanocomposites, the synergistic effects between metal elements often lead to excellent catalytic performance, even imparting unique properties that are not present in single metal elements. However, bimetallic alloys face issues of structural and … Read more

Inhibition of Breast Cancer Cells by Novel Nanoparticles Combined with Low-Intensity Focused Ultrasound

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Inhibition of Breast Cancer Cells by Novel Nanoparticles Combined with Low-Intensity Focused Ultrasound

Source Qian Zhang, Jiaxing Wang, Yanjun Ding, et al. Inhibition of Breast Cancer Cells by Novel Nanoparticles Combined with Low-Intensity Focused Ultrasound. Chinese Journal of Medical Imaging, 2020, 28(12): 907-911+917 Abstract Objective To explore the ability of the phase-change nanoparticles (Ce6@PFP/PLGA NPs) loaded with the sonosensitizer Chlorin e6 (Ce6) and perfluoropentane (PFP) combined with low-intensity … Read more

The Dual Role of Protein Corona in Tumor Targeting, Immunotherapy, and Diagnosis

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The Dual Role of Protein Corona in Tumor Targeting, Immunotherapy, and Diagnosis

Recently, Associate Professor Zhang Wenli’s team at China Pharmaceutical University published a review titled “The Janus of Protein Corona on Nanoparticles for Tumor Targeting, Immunotherapy and Diagnosis” in Journal of Controlled Release, Volume 345, 2022, and it was selected as the Inside Back Cover article of that issue.. Figure 1. The dual-edged effect of protein … Read more

Single-Dose Physically Cross-Linked Hyaluronic Acid and Lipid Hybrid Nanoparticles Activate Antitumor Immune Response

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Single-Dose Physically Cross-Linked Hyaluronic Acid and Lipid Hybrid Nanoparticles Activate Antitumor Immune Response

iNature Activating the STING pathway in the cytosol of tumor-infiltrating antigen-presenting cells (APCs) can trigger an effective antitumor immune response for cancer treatment. However, most STING agonists are hydrophilic small molecules that face rapid clearance and poor cytosolic delivery issues after systemic administration. Although various nanoparticles have been developed to facilitate cytosolic delivery, they often … Read more

Platinum(IV)-Backboned Polymer Prodrug-Functionalized Manganese Oxide Nanoparticles for Enhanced Lung Cancer Chemoimmunotherapy

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Platinum(IV)-Backboned Polymer Prodrug-Functionalized Manganese Oxide Nanoparticles for Enhanced Lung Cancer Chemoimmunotherapy

iNature The stimulator of interferon genes (STING) pathway shows great potential in reshaping the immunosuppressive tumor microenvironment and initiating anti-tumor immunity. However, effectively activating STING while avoiding toxic side effects from systemic administration remains challenging. On January 7, 2025, a communication from Li Weimin’s team at Sichuan University was published online in ACS Nano titled … Read more

Ferumoxytol Nanoparticles Target Biofilms Causing Tooth Decay

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Ferumoxytol Nanoparticles Target Biofilms Causing Tooth Decay

Research Background Cavities (tooth decay) are an unresolved public health issue affecting over 2.3 billion people worldwide, particularly among the impoverished and those with poor medical conditions. Notably, iron deficiency anemia is closely related to severe cavities. Current preventive measures are insufficient for at-risk populations, especially in severe cases where high-sugar diets and poor oral … Read more

Microfluidic Isolation and Enrichment of Nanoparticles

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Microfluidic Isolation and Enrichment of Nanoparticles

Xie Y, Rufo J, Zhong R, Rich J, Li P, Leong KW, Huang TJ. Microfluidic Isolation and Enrichment of Nanoparticles. ACS Nano. 2020 Dec 22;14(12):16220-16240. doi: 10.1021/acsnano.0c06336. Epub 2020 Nov 30. PMID: 33252215; PMCID: PMC8164652. In recent decades, the application of nanoparticles has increased in various applications, ranging from efficient electronics to targeted drug delivery. … Read more

Temperature-Driven Phase Transition and Element Segregation in Pd-Ru Nanoparticles

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Temperature-Driven Phase Transition and Element Segregation in Pd-Ru Nanoparticles

Bimetallic alloys can form three typical structures, including solid solution, heterogeneous structure, and intermetallic compounds, depending on the interactions between identical and different atoms. Although this trend can be predicted through the types of binary phase diagrams, different synthesis methods can trap the system in various dynamical intermediates between these three typical structures. Here, we … Read more

Efficient Electrocatalytic Hydrogen Evolution Using HEAs

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Efficient Electrocatalytic Hydrogen Evolution Using HEAs

High-entropy alloys (HEAs) have become promising candidate materials for hydrogen evolution reaction (HER) electrocatalysts due to their unique cocktail electronic effect and lattice distortion effect. In this study, ultra-small (less than 2 nanometers) nanoparticles of PtRuCoNiCu HEA were highly dispersed on hierarchical nitrogen-doped carbon nanocages (hNCNC) through a low-temperature thermal reduction method, referred to as … Read more

Cationic Magnetic Nanoparticles Enhance NK Cell Activity in GBM

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Cationic Magnetic Nanoparticles Enhance NK Cell Activity in GBM

iNature Glioblastoma (GBM) has an immune-suppressive microenvironment and blood-brain barrier (BBB) that severely hinders the infiltration and activity of natural killer (NK) cells, thereby reducing their clinical efficacy in GBM treatment. On December 23, 2024, Zhang Xianzheng from Wuhan University published a study titled “Cationic Magnetic Nanoparticles Activate Natural Killer Cells for the Treatment of … Read more