ADC Drug Combination: How to Achieve 1+1>2

ADC Drug Combination: How to Achieve 1+1>2

Antibody-drug conjugates (ADC) are a novel type of medication that couples monoclonal antibodies, which specifically recognize cancer cell surface antigens, with cytotoxic chemotherapy drugs through specific linkers, exerting a significant tumor-killing effect. Currently, 15 ADC drugs, represented by trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan (T-DXd, DS-8201), have been approved globally, significantly changing the treatment landscape … Read more

Cationic Magnetic Nanoparticles Enhance NK Cell Activity in GBM

Cationic Magnetic Nanoparticles Enhance NK Cell Activity in GBM

iNature Glioblastoma (GBM) has an immune-suppressive microenvironment and blood-brain barrier (BBB) that severely hinders the infiltration and activity of natural killer (NK) cells, thereby reducing their clinical efficacy in GBM treatment. On December 23, 2024, Zhang Xianzheng from Wuhan University published a study titled “Cationic Magnetic Nanoparticles Activate Natural Killer Cells for the Treatment of … Read more