Protection of Amines with Boc Group
Free amines easily react with NaOH or NaHCO3 under alkaline conditions controlled by a mixture of dioxane and water to produce N-tert-butoxycarbonylated amines via reaction with Boc2O. This is one of the commonly used methods for introducing Boc, which has the advantage of producing minimal interfering by-products that are easy to remove. For some nucleophilic … Read more
