Organic Synthesis

Professor Xu Haichao’s Research Group Achieves Significant Progress in Organic Electrosynthesis

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Professor Xu Haichao's Research Group Achieves Significant Progress in Organic Electrosynthesis

Research Updates Professor Xu Haichao’s research group, in collaboration with Professor Lang Kai’s team from Heilongjiang University, has made significant progress in the field of organic electrosynthesis. Their research, titled “Carbene Reactivity Directly from Aldehydes via Low-Valent Iron Electrocatalysis,” has been published online in the Journal of the American Chemical Society (DOI: 10.1021/jacs.5c17027). Carbenes are … Read more

Review by Professor Hongjian Lu’s Team at Nanjing University | Recent Advances in Skeleton Editing Based on Nitrogen Atom Manipulation

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Review by Professor Hongjian Lu's Team at Nanjing University | Recent Advances in Skeleton Editing Based on Nitrogen Atom Manipulation

–Paper Information– Professor Hongjian Lu’s team at Nanjing University has published the latest research progress on nitrogen atom manipulation in skeleton editing in the top international journal《Chem. Soc. Rev.》. –Research Background– The development of new strategies for the efficient activation of inert chemical bonds has opened up new pathways for constructing structurally unique and complex … Read more

Common Reagent – PhI(OAc)2

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Common Reagent - PhI(OAc)2

Name: (Diacetoxyiodo)benzene, (二乙酰氧基碘)苯 Formula: C10H11IO4 Molecular Weight: 322.10 CAS Registration Number: [3240-34-4] Abbreviations and Aliases: DIB, Iodobenzene Diacetate Physical Properties: mp 163~165 °C, soluble in most organic solvents. Commonly used in MeOH, MeCN, and AcOH solvents. Preparation and Commercial Availability: The commercial reagent is a white solid, available from foreign reagent companies. It can be … Read more

Corey-Bakshi-Shibata Reduction Reaction

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Corey-Bakshi-Shibata Reduction Reaction

The Corey–Bakshi–Shibata (CBS) reagent is a chiral catalyst prepared from proline. Also known as Corey boron-containing oxazolidine, it can be used with boranes for enantioselective reduction of ketones, imides, and imines, and can also serve as a Lewis acid to catalyze asymmetric Diels–Alder reactions and [3 + 2] cycloadditions. This catalyst is easy to prepare, … Read more

Multi-Kg Production of 3-Fluoro-6-methoxyquinoline

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Multi-Kg Production of 3-Fluoro-6-methoxyquinoline

Org. Process Res. Dev. 2022, 26, 347. DOI: 10.1021/acs.oprd.1c00414 Route A ◆During the aqueous quench, a certain degree of back-hydrolysis to 2 occurred, which contaminated the initial crude product. The problem was solved by performing the chlorination with diphenylphosphoryl chloride (1.5 equiv) in DMF (5.5 vol). ◆For the Hofmann rearrangement of 11, the conditions reported … Read more

One-Carbon Insertion Reaction of Aromatic C-N Bonds: Efficient Synthesis of Chiral Benzylamines

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One-Carbon Insertion Reaction of Aromatic C-N Bonds: Efficient Synthesis of Chiral Benzylamines

1. When Aniline Meets“Molecular Surgery”: An Innovative Path to Break Aromaticity In the world of organic synthesis, aniline acts like a “stubborn guardian” — the carbon-nitrogen bond (C-N) on its aromatic ring is highly stable and difficult to modify directly. However, chiral α-branched benzylamines, as core scaffolds for drug molecules (such as analgesics and antibiotics) … Read more

The Latest and Most Comprehensive Study on the Polarity of Free Radical Intermediates

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The Latest and Most Comprehensive Study on the Polarity of Free Radical Intermediates

The polarity of free radical intermediates has a profound impact on their reactivity and selectivity. To quantify this effect and predict its outcomes, the Nagib research group at Ohio State University calculated the electrophilicity/nucleophilicity of over 500 types of free radicals. The figure also includes a simple “rule of thumb” for qualitatively predicting free radical … Read more

Electrocatalytic Decarboxylation Csp3–N Coupling: Baran Team’s Excellent Preparation of Aryl N-Tert-alkyl Derivatives

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Electrocatalytic Decarboxylation Csp3–N Coupling: Baran Team's Excellent Preparation of Aryl N-Tert-alkyl Derivatives

Phil S. Baran and his team have pioneered many astonishing electrocatalytic reactions with extraordinary creativity and foresight, which not only provide unprecedented green and efficient chemical synthesis but also offer scientists more elegant and sophisticated tools. His research has injected new vitality into the field of electrocatalysis, shining like a dazzling light, leading the chemistry … Read more

Protection of Amines with Boc Group

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Protection of Amines with Boc Group

Free amines easily react with NaOH or NaHCO3 under alkaline conditions controlled by a mixture of dioxane and water to produce N-tert-butoxycarbonylated amines via reaction with Boc2O. This is one of the commonly used methods for introducing Boc, which has the advantage of producing minimal interfering by-products that are easy to remove. For some nucleophilic … Read more

New Stable Aryl Boronic Esters on Silica Gel with Higher Suzuki-Miyaura Reaction Activity!

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New Stable Aryl Boronic Esters on Silica Gel with Higher Suzuki-Miyaura Reaction Activity!

Due to WeChat’s changes to subscription account push rules, many friends cannot quickly find us, but we are actually pushing every day!You can set Organic Synthesis as a star (click the upper right “…” to set it as a star), so you can quickly find us in the WeChat subscription account and check the daily … Read more