1. When Aniline Meets“Molecular Surgery”: An Innovative Path to Break Aromaticity In the world of organic synthesis, aniline acts like a “stubborn guardian” — the carbon-nitrogen bond (C-N) on its aromatic ring is highly stable and difficult to modify directly. However, chiral α-branched benzylamines, as core scaffolds for drug molecules (such as analgesics and antibiotics) … Read more
The polarity of free radical intermediates has a profound impact on their reactivity and selectivity. To quantify this effect and predict its outcomes, the Nagib research group at Ohio State University calculated the electrophilicity/nucleophilicity of over 500 types of free radicals. The figure also includes a simple “rule of thumb” for qualitatively predicting free radical … Read more
Phil S. Baran and his team have pioneered many astonishing electrocatalytic reactions with extraordinary creativity and foresight, which not only provide unprecedented green and efficient chemical synthesis but also offer scientists more elegant and sophisticated tools. His research has injected new vitality into the field of electrocatalysis, shining like a dazzling light, leading the chemistry … Read more
Free amines easily react with NaOH or NaHCO3 under alkaline conditions controlled by a mixture of dioxane and water to produce N-tert-butoxycarbonylated amines via reaction with Boc2O. This is one of the commonly used methods for introducing Boc, which has the advantage of producing minimal interfering by-products that are easy to remove. For some nucleophilic … Read more
Due to WeChat’s changes to subscription account push rules, many friends cannot quickly find us, but we are actually pushing every day!You can set Organic Synthesis as a star (click the upper right “…” to set it as a star), so you can quickly find us in the WeChat subscription account and check the daily … Read more