One-Carbon Insertion Reaction of Aromatic C-N Bonds: Efficient Synthesis of Chiral Benzylamines
1. When Aniline Meets“Molecular Surgery”: An Innovative Path to Break Aromaticity In the world of organic synthesis, aniline acts like a “stubborn guardian” — the carbon-nitrogen bond (C-N) on its aromatic ring is highly stable and difficult to modify directly. However, chiral α-branched benzylamines, as core scaffolds for drug molecules (such as analgesics and antibiotics) … Read more