Synergistic Construction of Chiral Carbon Centers via Photocatalytic Nickel Catalysis

Synergistic Construction of Chiral Carbon Centers via Photocatalytic Nickel Catalysis

Image source: J. Am. Chem. Soc.Introduction: The enantioselective alkyl-alkyl cross-coupling is a powerful and challenging strategy for constructing three-dimensional molecular structures, which hold significant value in organic chemistry and medicinal chemistry. Although radical-radical cross-coupling provides a feasible pathway to achieve this goal, controlling the cross-selectivity and enantioselectivity between two different alkyl radicals remains a significant … Read more

Corey-Bakshi-Shibata Reduction Reaction

Corey-Bakshi-Shibata Reduction Reaction

The Corey–Bakshi–Shibata (CBS) reagent is a chiral catalyst prepared from proline. Also known as Corey boron-containing oxazolidine, it can be used with boranes for enantioselective reduction of ketones, imides, and imines, and can also serve as a Lewis acid to catalyze asymmetric Diels–Alder reactions and [3 + 2] cycloadditions. This catalyst is easy to prepare, … Read more