1 In the past two years, the market price of Yangtze River knife fish has shown a significant rebound. This is because the catch of knife fish in the past two years is only a fraction of what it was two or three decades ago, and there is also a considerable difference compared to five … Read more
Introduction Although rare, intrahepatic cholangiocarcinoma (ICC) is the second most common primary malignant tumor of the liver, with approximately 8,000 cases diagnosed annually in the United States, accounting for only 3% of gastrointestinal malignancies diagnosed worldwide each year. The incidence of ICC has increased over the past few decades, with some studies indicating a 14% … Read more
Written by | Yi The chromatin maps at gene locus resolution can reflect gene regulatory features, helping researchers define cell types and developmental trajectories. In recent years, genomic localization methods for epigenetic-related proteins have been applied at the single-cell level, such as CUT&Tag (Cleavage Under Targets & Tagmentation) based on Tn5 transposase【1,2】. However, mapping and … Read more
Click the blue text above to follow us Bisulfite Sequencing (BSP) is a DNA methylation detection technology based on bisulfite conversion. The core principle is to chemically treat DNA with bisulfite, converting unmethylated cytosine (C) to uracil (U), while methylated cytosine (5-methylcytosine, 5mC) remains unchanged. The converted DNA is amplified by PCR and sequenced, allowing … Read more
Source: Wang Xin, Rao Benqiang. High-Dose Vitamin C Precision Therapy for Tumors [J/CD]. Journal of Tumor Metabolism and Nutrition, 2023, 10(3): 307-312. Article link: http://182.92.200.144/CN/abstract/abstract1016.shtml Expert Introduction Rao Benqiang, Deputy Director of the Second Department of Gastrointestinal Surgery at Beijing Shijitan Hospital, Capital Medical University, Deputy Director of the National Market Supervision Key Laboratory (Tumor … Read more
Antibody drug conjugates (antibody drug conjugate, ADC) are a class of emerging targeted anti-cancer drugs that have shown excellent efficacy in clinical trials against various refractory and metastatic solid tumors. However, the therapeutic effects and potential biological mechanisms of ADC drugs used in combination with other targeted therapies remain unexplored. Recently, Researcher Guo Peng from … Read more
◆ ◆ ◆ ◆ Sci Adv | Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection Technological innovation is a crucial engine for modern life sciences research. Each iteration and update of biotechnology brings disruptive changes to the life sciences field. In recent years, single-cell sequencing technology has developed rapidly, propelling scientists worldwide … Read more