multi-omics

Breaking Through the Challenges of Spatial Multi-Omics Integration! The MultiGATE Tool Emerges to Precisely Decode Tissue Microenvironments and Regulatory Networks

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Breaking Through the Challenges of Spatial Multi-Omics Integration! The MultiGATE Tool Emerges to Precisely Decode Tissue Microenvironments and Regulatory Networks

In today’s rapidly developing field of spatial biology, spatial multi-omics technology can simultaneously capture multi-dimensional molecular information such as transcriptomes, epigenomes, and proteins from the same tissue slice, providing unprecedented opportunities for analyzing tissue heterogeneity and molecular regulatory mechanisms. However, efficiently integrating these multimodal data while mining spatial information and cross-modal regulatory relationships has been … Read more

Literature Sharing | J Am Chem Soc: Quantitative Analysis of Single-Cell High-Throughput Multi-Omics Aptomics

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Literature Sharing | J Am Chem Soc: Quantitative Analysis of Single-Cell High-Throughput Multi-Omics Aptomics

High-throughput sequencing technology is driving the life sciences towards a quantitative paradigm, but the sequencing technologies for antibodies, glycans, and other non-directly measurable molecules face challenges such as complex coupling steps, steric hindrance, and the labor-intensive nature of enzymatic chemical labeling. Aptamers, as nucleic acid molecules that can be sequenced directly, possess high specificity, broad … Read more

Upgraded ‘Mind Reading’ in the Cellular World! MultiKano: A Data Augmentation Method Based on Cutting-Edge Mathematics and AI to Decode Single-Cell Multi-Omics Identity Codes

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Upgraded 'Mind Reading' in the Cellular World! MultiKano: A Data Augmentation Method Based on Cutting-Edge Mathematics and AI to Decode Single-Cell Multi-Omics Identity Codes

Sharing an article co-authored by Associate Professor Chen Shengquan from Nankai University and Associate Professor Yang Qingzhu from the Capital University of Physical Education and Sports, published in the journal Protein & Cell. The title is “Development of MultiKano: An Automated Cell Type Annotation Tool Based on Kolmogorov-Arnold Networks and Data Augmentation for Cell Type … Read more

MultiKano: An Automatic Cell Type Annotation Method for Single-Cell Multi-Omics Data

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MultiKano: An Automatic Cell Type Annotation Method for Single-Cell Multi-Omics Data

The rapid development of single-cell multi-omics sequencing technology has made it possible to measure gene expression and chromatin accessibility simultaneously, providing a comprehensive view of gene regulatory mechanisms at single-cell resolution. Cell type annotation is a core step in the analysis of single-cell multi-omics data. Common cell type annotation methods typically involve unsupervised clustering followed … Read more

Deep Learning + Multi-Omics Data (DL + Multi-Omics): Applications in Cancer Research

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Deep Learning + Multi-Omics Data (DL + Multi-Omics): Applications in Cancer Research

Cancer, as a highly heterogeneous disease, involves complex changes across multiple layers, including the genome, epigenome, transcriptome, proteome, and metabolome. In recent years, with the rapid development of high-throughput sequencing technologies, the integrated analysis of multi-omics data has provided unprecedented opportunities for cancer research. Deep learning (DL) technology can analyze high-dimensional datasets to discover new … Read more

Exploring GeoMx DSP Applications in Cancer Research

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Exploring GeoMx DSP Applications in Cancer Research

Introduction GeoMx® Digital Spatial Profiler (DSP) is one of the leading revolutionary technologies that elevate spatial biology to new heights and is a core force in driving the forefront of spatial multi-omics research and clinical translation practices. It meets the research and application needs at different stages across various fields such as oncology, tumor immunology, … Read more

Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection

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Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection

◆ ◆ ◆ ◆ Sci Adv | Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection Technological innovation is a crucial engine for modern life sciences research. Each iteration and update of biotechnology brings disruptive changes to the life sciences field. In recent years, single-cell sequencing technology has developed rapidly, propelling scientists worldwide … Read more