Overcoming the Challenge of Meta-Methylation of Pyridine: A Cost-Effective Aldehyde-Catalyzed Strategy Brings New Breakthroughs
Image source: J. Am. Chem. Soc.Introduction:The introduction of methyl groups can significantly enhance the activity of drugs, thus driving the development of various methylation strategies. Among these, C-H methylation is particularly noteworthy, but a universal method for meta-C-H methylation of pyridine—one of the most common nitrogen-containing heterocycles in pharmacophores—remains absent. This article reports a method … Read more
