Written by | Yi The chromatin maps at gene locus resolution can reflect gene regulatory features, helping researchers define cell types and developmental trajectories. In recent years, genomic localization methods for epigenetic-related proteins have been applied at the single-cell level, such as CUT&Tag (Cleavage Under Targets & Tagmentation) based on Tn5 transposase【1,2】. However, mapping and … Read more
Sharing an article co-authored by Associate Professor Chen Shengquan from Nankai University and Associate Professor Yang Qingzhu from the Capital University of Physical Education and Sports, published in the journal Protein & Cell. The title is “Development of MultiKano: An Automated Cell Type Annotation Tool Based on Kolmogorov-Arnold Networks and Data Augmentation for Cell Type … Read more
The rapid development of single-cell multi-omics sequencing technology has made it possible to measure gene expression and chromatin accessibility simultaneously, providing a comprehensive view of gene regulatory mechanisms at single-cell resolution. Cell type annotation is a core step in the analysis of single-cell multi-omics data. Common cell type annotation methods typically involve unsupervised clustering followed … Read more
◆ ◆ ◆ ◆ Sci Adv | Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection Technological innovation is a crucial engine for modern life sciences research. Each iteration and update of biotechnology brings disruptive changes to the life sciences field. In recent years, single-cell sequencing technology has developed rapidly, propelling scientists worldwide … Read more
