HiFi-C Sample Submission Process: How to Prepare for Optimal Data Collection

HiFi-C Sample Submission Process: How to Prepare for Optimal Data Collection

HiFi-C (High-Fidelity Chromosome Conformation Capture) is a high-fidelity chromatin conformation capture technology based on high-throughput sequencing. It captures the spatial interactions of chromatin within the nucleus, allowing for precise analysis of the three-dimensional structure of the genome (such as TADs and chromatin loops) and the interaction patterns of gene regulatory elements (promoter-enhancer interactions). This technology … Read more

NBT | MulTI-Tag: Multi-Factor Epigenetic Mapping at Single-Cell Resolution

NBT | MulTI-Tag: Multi-Factor Epigenetic Mapping at Single-Cell Resolution

Written by | Yi The chromatin maps at gene locus resolution can reflect gene regulatory features, helping researchers define cell types and developmental trajectories. In recent years, genomic localization methods for epigenetic-related proteins have been applied at the single-cell level, such as CUT&Tag (Cleavage Under Targets & Tagmentation) based on Tn5 transposase【1,2】. However, mapping and … Read more