Transforming Cancer-Associated Fibroblast Barriers for Tumor Treatment

The cancer-associated fibroblast (CAF) barrier in pancreatic ductal adenocarcinoma (PDAC) significantly restricts clinical prognosis. The main obstacles in PDAC treatment include limited immune cell and drug penetration, as well as an immunosuppressive microenvironment. Based on this, Yongjun Liu and Na Zhang from Shandong University reported a “shooting fish in a barrel” strategy by preparing a … Read more

PyQt5 Example: Raspberry Pi + MPU6050 Data Collection

Click the above“Mechanical and Electronic Engineering Technology” to follow us System Configuration: Raspberry Pi 3B+, Operating System Raspbian-stretch, Python version is python3.5.3 Functional Requirements: Design a QT interface to collect data, with a start collection button that begins data collection when clicked, and a stop button that stops data collection when clicked. The data should … Read more

Oxygen Vacancy Piezoelectric Nanosheets for Ultrasound Tumor Therapy

Piezoelectric Dynamic Therapy (PzDT) is a tumor treatment method that utilizes mechanical energy to trigger the polarization of piezoelectric materials. Under the action of ultrasound (US), the immense pressure generated by the collapse of cavitation bubbles serves as a mechanical force source for the piezoelectric sonosensitizer, showing feasible potential. An internal electric field can form … Read more

In Situ Electron Microscopy Study of Dynamic Structural Changes in CuZn Bimetallic Nanoparticles

Background Introduction Bimetallic nanocomposites have gained widespread attention due to their tunable physicochemical properties and significant applications in engineering and catalysis. In nanocomposites, the synergistic effects between metal elements often lead to excellent catalytic performance, even imparting unique properties that are not present in single metal elements. However, bimetallic alloys face issues of structural and … Read more

Multicomponent Herbal Small Molecule Hydrogels for TBI Treatment

iNature Self-assembling hydrogels for mechanical support and drug delivery have been widely studied in the context of traumatic brain injury (TBI). However, most self-assembling hydrogels rely on polymer carriers or the introduction of exogenous inactive substances, often raising biosafety concerns and making clinical translation difficult. On October 9, 2024, a research paper titled “Small Molecule … Read more

Cold Exposure Therapy Enhances Breast Cancer Treatment

iNature Cold exposure therapy (CE) is a low-cost, non-invasive treatment for malignant tumors. When the body is exposed to a cold environment, it activates the thermogenic metabolism of brown adipose tissue (BAT), quickly inducing tumor starvation and inhibiting tumor growth. The microenvironmental changes caused by CE can further complement conventional treatments (such as radiotherapy and … Read more

Building a Portable PyPI Server with Raspberry Pi

In this article, I will discuss how to clone the PyPI repository onto a Raspberry Pi and provide content so that connected devices can install dependencies using the <span>pip install</span> command without an internet connection. Objective There are many ways to create your own PyPI mirror, and my method may be suitable for everyone now. … Read more

Self-Oxygenating & Glutathione-Depleting Microneedle Patch for Photodynamic Therapy of Tumors

Photodynamic therapy (PDT), as a non-invasive treatment for tumors, has garnered widespread attention. However, the hypoxia of solid tumors, the skin phototoxicity of “always-on” photosensitizers (PSs), and the abundant supply of glutathione (GSH) in cancer cells severely hinder the clinical application of PDT. To address this issue, the team from the First Affiliated Hospital of … Read more

Brain-Inspired Computing Needs A Master Plan

Introduction With the increasing demand for computing power, the energy consumption of modern computing systems is also rising, making it challenging to support the sustainable future development of artificial intelligence technologies. This energy issue largely stems from the traditional digital computing systems employing the classic von Neumann architecture, where data processing and storage occur in … Read more

Using Holographic 3D Imaging to Observe Virus-Induced Cytopathic Effects

Cytopathic effects (CPEs) are a hallmark of infection. Due to the phototoxicity of classical optical microscopy, CPEs are difficult to observe. This study reports different patterns of viral infection in live cells using Digital HoloTomographic Microscopy (DHTM). DHTM is label-free and records the phase shift of low-energy light passing through the sample on a transparent … Read more