Research Perspective: Single Neuron – Single Cell Resolution Trace-n-seq

Research Perspective: Single Neuron - Single Cell Resolution Trace-n-seq

The peripheral nervous system (PNS) coordinates organ function in health and disease. Most cancers, including pancreatic ductal adenocarcinoma (PDAC), are associated with PNS neurons, leading to a complex tumor microenvironment (TME). However, neuronal cell bodies exist in various PNS ganglia, away from tumor masses. Therefore, neurons innervating cancer or healthy organs have evaded current tissue … Read more

Transforming Cancer-Associated Fibroblast Barriers for Tumor Treatment

Transforming Cancer-Associated Fibroblast Barriers for Tumor Treatment

The cancer-associated fibroblast (CAF) barrier in pancreatic ductal adenocarcinoma (PDAC) significantly restricts clinical prognosis. The main obstacles in PDAC treatment include limited immune cell and drug penetration, as well as an immunosuppressive microenvironment. Based on this, Yongjun Liu and Na Zhang from Shandong University reported a “shooting fish in a barrel” strategy by preparing a … Read more